CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12672
Family Name 5-hydroxytryptamine receptor 7 and Alpha-2C adrenergic receptor ligand (2S)-5-(2,6-dimethoxyphenyl)-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00283603 Functional Category Bioactive
Superfamily Transporter and Alpha-2C adrenergic receptor Binder Superfamily
Class Class 280

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Sigma non-opioid intracellular receptor 1 ligand opiate Dextro... 9 33
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 4 35
D(3) dopamine receptor Ligand U-99194A Family 7 33
Oxi4503 family 4 27
Acolbifene family 10 115
Dapoxetine family 3 40
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
Platelet-activating factor receptor Ligand L-652731 Family 5 116
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Glucocorticoid receptor Ligand 1-methoxy-6-phenyl-6h-benzo[c]c... 2 22
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-... 3 9
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Histamine H3 receptor Ligand 1-(3-(2-(3-methoxyphenoxy)ethoxy)... 3 9
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Aromatase Inhibitor 2,3,4-trimethoxy-4'-amino-trans-stilbene F... 9 14
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
Androgen receptor Ligand Palodesangren E Family 12 43
D(3) dopamine receptor ligand S 14297 family 1 2
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 7


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00417632 CHEMBL232791 Bioactive AGN-PC-04URXV

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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