CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1268
Family Name Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha and Protein farnesyltransferase subunit beta inhibitor (2S)-2-[[2-[[(2S)-2-[[2-(3-benzylimidazol-4-yl)acetyl]amino]-3-methylpentyl]-(naphthalen-1-ylmethyl)amino]acetyl]amino]-4-methylsulfanylbutanoic acid family
No. of Seeds 11 No. of Other Members 22
Family Centroid CFAMM00321247 Functional Category Bioactive
Superfamily Protein farnesyltransferase subunit beta and Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Binder Superfamily 2
Class Class 1170

Cousin Family NamesSeedsMembers
Parathyroid hormone/parathyroid hormone-related peptide recept... 55 256
Insulin-degrading enzyme inhibitor cyclic polypeptide Bacitrac... 30 259
Renin Inhibitor Remikiren Family 100 126
Growth hormone receptor Ligand EP-51216 Family 34 390
Eluxadoline family 4 85
Farnesyltransferase beta subunit, putative and Protein farnesy... 20 81
Renin Inhibitor (h-261)boc-his-pro-phe-his-leu(oh)-val-ile-his... 33 41
Integrin alpha-V and Integrin beta-3 Inhibitor SB-223245 Family 27 36
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 8
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 2
Renin inhibitor propan-2-yl (3R)-2-hydroxy-3-[[(2S)-3-(1H-imid... 4 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 9 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 3... 5 14
Pol polyprotein inhibitor propan-2-yl N-[(2S)-1-[[(2S,3S,5R)-3... 6 2
Delta-type opioid receptor ligand ethyl N-[3-[(R)-[4-[ethyl(me... 2 6
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Type-1A angiotensin II receptor ligand 2-[[2-butyl-3-[(4-carbo... 2 4
Integrin alpha-V and Integrin beta-6 inhibitor 3-[[2-[4-[(4-me... 4 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor (2S)-2... 2 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 3
Angiotensin-converting enzyme 2 inhibitor MLN-4760 family 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00321247 CHEMBL322355 Bioactive (2S)-2-[[2-[[(2S)-2-[[2-(3-benzylimidazol-4-yl)acetyl]amino]-3-methylpentyl]-(naphthalen-1-ylmethyl)amino]acetyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00321260 CHEMBL326745 Bioactive (2S)-2-[[2-[[(2S)-3-methyl-2-[[2-[1-[(4-nitrophenyl)methyl]imidazol-4-yl]acetyl]amino]pentyl]-(naphthalen-1-ylmethyl)amino]acetyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00321259 CHEMBL325840 Bioactive (2S)-4-methylsulfanyl-2-[[2-[[(2S)-3-methyl-2-[[2-[3-[(2E,7E)-3,8,12-trimethyltrideca-2,7,11-trienyl]imidazol-4-yl]acetyl]amino]pentyl]-(naphthalen-1-ylmethyl)amino]acetyl]amino]butanoic acid
CFAMM00321231 CHEMBL115502 Bioactive (2S)-2-[[2-[[(2S)-2-[[2-[3-[(2E)-3,7-dimethylocta-2,6-dienyl]imidazol-4-yl]acetyl]amino]-3-methylpentyl]-(naphthalen-1-ylmethyl)amino]acetyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00321258 CHEMBL327106 Bioactive (2S)-2-[[2-[[(2S)-3-methyl-2-[[2-[3-(naphthalen-1-ylmethyl)imidazol-4-yl]acetyl]amino]pentyl]-(naphthalen-1-ylmethyl)amino]acetyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00321251 CHEMBL324081 Bioactive (2S)-2-[[2-[[(2S)-3-methyl-2-[[2-[3-[(4-nitrophenyl)methyl]imidazol-4-yl]acetyl]amino]pentyl]-(naphthalen-1-ylmethyl)amino]acetyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00321256 CHEMBL325396 Bioactive (2S)-2-[[2-[[(2S)-3-methyl-2-[[2-[3-(pyridin-4-ylmethyl)imidazol-4-yl]acetyl]amino]pentyl]-(naphthalen-1-ylmethyl)amino]acetyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00321249 CHEMBL114990 Bioactive (2S)-2-[[2-[[(2S)-3-methyl-2-[[2-[3-(quinolin-2-ylmethyl)imidazol-4-yl]acetyl]amino]pentyl]-(naphthalen-1-ylmethyl)amino]acetyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00321262 CHEMBL326210 Bioactive (2S)-2-[[2-[[(2S)-2-[[2-[3-[(4-fluorophenyl)methyl]imidazol-4-yl]acetyl]amino]-3-methylpentyl]-(naphthalen-1-ylmethyl)amino]acetyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00321255 CHEMBL321252 Bioactive (2S)-2-[[2-[[(2S)-3-methyl-2-[[2-[3-(naphthalen-2-ylmethyl)imidazol-4-yl]acetyl]amino]pentyl]-(naphthalen-1-ylmethyl)amino]acetyl]amino]-4-methylsulfanylbutanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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