CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12685
Family Name G-protein coupled bile acid receptor 1 ligand 2-(ethylamino)-6-[3-[4-(2,2,2-trifluoroethyl)phenyl]propanoyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-4-carboxamide family
No. of Seeds 5 No. of Other Members 4
Family Centroid CFAMM00417692 Functional Category Bioactive
Superfamily Mitogen-activated protein kinase 12 Inhibitor SB681323 Superfamily
Class Class 824

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Prothrombin Inhibitor Dabigatran Family 7 182
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Mitogen-activated protein kinase 12 Inhibitor VX-702 Family 3 49
C-C chemokine receptor type 5 Ligand Vicriviroc Family 4 31
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Dipeptidyl peptidase 4 Inhibitor SSR-162369 Family 8 27
RAC-gamma serine/threonine-protein kinase Inhibitor GDC-0068 F... 20 29
Serine/threonine-protein kinase mTOR Inhibitor AZD2014 Family 2 41
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
PHA848125 family 13 138
JAK Inhibitor Momelotinib Family 33 83
Toll-like receptor 7 Ligand GS-9620 Family 2 4
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
XL-888 family 16 85
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(6-methylpy... 4 3
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
Adenosine receptor A1 Ligand N-(4,6-diphenylpyrimidin-2-yl)ben... 4 8
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Adenosine receptor A3 Ligand 2-aminoquinazoline-4-carboxyanili... 4 3
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SCH-577... 9 29
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 6-(4-... 3 6
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 11
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-amin... 10 48
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
C-C chemokine receptor type 5 ligand [3-[2-[(3aS,6aR)-5-(4,6-d... 3 40
Integrin beta-3 and Integrin alpha-V inhibitor SureCN547914 fa... 8 32
Dipeptidyl peptidase 4 inhibitor AGN-PC-046QKE family 3 5
Substance-P receptor ligand (3R,4S)-N-[[3,5-bis(trifluoromethy... 3 7
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Cathepsin K and Potassium voltage-gated channel subfamily H me... 5 1
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZB72 family 10 8
C-C chemokine receptor type 5 ligand AC1NUXE1 family 12 7
Survival motor neuron protein inhibitor CHEMBL1583999 family 1 3
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
C-C chemokine receptor type 5 ligand SureCN3684128 family 2 2
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 3 5
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 10 14
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Delta-type opioid receptor ligand ethyl N-[3-[(R)-[4-[ethyl(me... 2 6
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 3 0
5-hydroxytryptamine receptor 3A ligand 3-methyl-N-[7-[[3-methy... 2 0
Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]... 3 1
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Substance-P receptor ligand Netupitant family 5 2
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 2 0
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor 6-... 1 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Orexin receptor type 2 and Orexin receptor type 1 ligand (2R)-... 12 16
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 3 0
C-C chemokine receptor type 5 ligand N-[3-[4-[3-cyclohexyl-5-(... 5 4
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(3-fluor... 10 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 2
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RDJ family 15 1
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin... 3 3
Transient receptor potential cation channel subfamily V member... 3 2
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Poly [ADP-ribose] polymerase 1 inhibitor Piperazine analogue, ... 4 0
Collagenase 3 inhibitor MMP-13 Inhibitor family 1 1
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 1
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 0
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
C-C chemokine receptor type 5 ligand AC1MHPAK family 5 1
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 1 11
Dipeptidyl peptidase 4 inhibitor AGN-PC-046QKJ family 1 0
Corticotropin-releasing factor receptor 1 ligand [6-[cycloprop... 6 3
Cannabinoid receptor 2 ligand AGN-PC-00SRU5 family 2 0
Histone deacetylase 1 inhibitor N-(2-aminophenyl)-4-[[[4-(cycl... 5 3
Histone deacetylase 1 inhibitor N-(2-aminophenyl)-4-[[(4,6-dim... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00417693 CHEMBL2331651 Bioactive 6-[3-[4-(1,1-difluoroethyl)phenyl]propanoyl]-2-(ethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-4-carboxamide
CFAMM00417692 CHEMBL2331650 Bioactive 2-(ethylamino)-6-[3-[4-(2,2,2-trifluoroethyl)phenyl]propanoyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-4-carboxamide
CFAMM00417698 CHEMBL2331649 Bioactive 2-(ethylamino)-6-[3-[4-(trifluoromethylsulfanyl)phenyl]propanoyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-4-carboxamide
CFAMM00417697 CHEMBL2331645 Bioactive 2-(ethylamino)-6-[3-(4-ethylphenyl)propanoyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-4-carboxamide
CFAMM00417696 CHEMBL2331646 Bioactive 2-(ethylamino)-6-[3-(4-propan-2-ylphenyl)propanoyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-4-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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