CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12687
Family Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform and Serine/threonine-protein kinase mTOR inhibitor 8-(6-methoxypyridin-3-yl)-3-methyl-1-(1-methylpiperidin-4-yl)imidazo[4,5-c][1,5]naphthyridin-2-one family
No. of Seeds 5 No. of Other Members 0
Family Centroid CFAMM00393338 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase mTOR and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Binder Superfamily 6
Class Class 3274

Cousin Family NamesSeedsMembers
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Integrin beta-3 and Integrin alpha-V inhibitor methyl (3S)-3-(... 12 13
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 11
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 42 3
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 3 1
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00417714 CHEMBL2331659 Bioactive 1-(4-hydroxycyclohexyl)-8-(6-methoxypyridin-3-yl)-3-methylimidazo[4,5-c][1,5]naphthyridin-2-one
CFAMM00417713 CHEMBL2331658 Bioactive 1-[4-(2-hydroxyethoxy)cyclohexyl]-8-(6-methoxypyridin-3-yl)-3-methylimidazo[4,5-c][1,5]naphthyridin-2-one
CFAMM00417712 CHEMBL2331661 Bioactive 1-(1-acetylpiperidin-4-yl)-8-(6-methoxypyridin-3-yl)-3-methylimidazo[4,5-c][1,5]naphthyridin-2-one
CFAMM00417711 CHEMBL2331657 Bioactive 2-[4-[8-(6-methoxypyridin-3-yl)-3-methyl-2-oxoimidazo[4,5-c][1,5]naphthyridin-1-yl]phenyl]-2-methylpropanenitrile

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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