CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12689
Family Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform and Serine/threonine-protein kinase mTOR inhibitor 1-(1-acetylpiperidin-4-yl)-8-(1H-indazol-4-yl)-3-methylimidazo[4,5-c][1,5]naphthyridin-2-one family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00417721 Functional Category Bioactive
Superfamily Calcitonin gene-related peptide type 1 receptor and Cytochrome P450 2D6 Ligand BMS-694153 Superfamily
Class Class 843

Cousin Family NamesSeedsMembers
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
PF-4217903 family 14 65
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
TGF-beta receptor type-1 Ligand Naphthyridine Inhibitor Family 3 6
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 19 12
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 10 1
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Smoothened homolog inhibitor (8aS)-N-[2-(3-chlorophenyl)pyrazo... 2 0
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Calcitonin gene-related peptide type 1 receptor ligand 2-[(7-m... 3 0
Calcitonin gene-related peptide type 1 receptor ligand [2-(7-m... 14 0
Calcitonin gene-related peptide type 1 receptor ligand 3-[1-[4... 5 3
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 5 3
Hepatocyte growth factor receptor ligand 5-(3-methyl-1,2-thiaz... 5 2
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 6
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 16 0
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 5 0
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 6 4
TGF-beta receptor type-1 ligand N-(3-cyanophenyl)-2-[3-(6-meth... 4 5
TGF-beta receptor type-1 ligand SureCN373106 family 4 1


External ID

Functional Category

Molecule Name

CFAMM00417721 CHEMBL2331667 Bioactive 1-(1-acetylpiperidin-4-yl)-8-(1H-indazol-4-yl)-3-methylimidazo[4,5-c][1,5]naphthyridin-2-one
CFAMM00417720 CHEMBL2331669 Bioactive 1-[1-[(2S)-2-hydroxypropanoyl]piperidin-4-yl]-8-(1H-indazol-4-yl)-3-methylimidazo[4,5-c][1,5]naphthyridin-2-one

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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