CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12693
Family Name Beta-secretase 2 and Beta-secretase 1 inhibitor N-[3-[(1S,7S)-5-amino-4-thia-6-azabicyclo[5.1.0]oct-5-en-7-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide family
No. of Seeds 7 No. of Other Members 4
Family Centroid CFAMM00417744 Functional Category Bioactive
Superfamily Beta-secretase 1 and Beta-secretase 2 Binder Superfamily 8
Class Class 913

Cousin Family NamesSeedsMembers
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Prothrombin inhibitor SureCN7371121 family 13 3
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 2 11
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Beta-secretase 1 inhibitor N-[3-[(4R,5R,6S)-2-amino-5-fluoro-4... 4 11
Beta-secretase 1 and Beta-secretase 2 inhibitor N-[3-[(4S)-2-a... 6 4
Beta-secretase 1 and Beta-secretase 2 inhibitor SureCN14726714... 4 1
Poly [ADP-ribose] polymerase 1 inhibitor SureCN3553433 family 22 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R9GP family 5 0


External ID

Functional Category

Molecule Name

CFAMM00417748 CHEMBL2331709 Bioactive N-[3-(5-amino-4-thia-6-azabicyclo[5.1.0]oct-5-en-7-yl)-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
CFAMM00417749 CHEMBL2347211 Bioactive N-[3-[(4S)-2-amino-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
CFAMM00417747 CHEMBL2331708 Bioactive N-[3-[(1S,7S)-5-amino-4-thia-6-azabicyclo[5.1.0]oct-5-en-7-yl]phenyl]-5-chloropyridine-2-carboxamide
CFAMM00417746 CHEMBL2347212 Bioactive N-[3-[(4R)-2-amino-5,5-difluoro-4-methyl-6H-1,3-thiazin-4-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
CFAMM00417744 CHEMBL2331712 Bioactive N-[3-[(1S,7S)-5-amino-4-thia-6-azabicyclo[5.1.0]oct-5-en-7-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
CFAMM00417743 CHEMBL2331713 Bioactive N-[3-[(1S,7S)-5-amino-4-thia-6-azabicyclo[5.1.0]oct-5-en-7-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
CFAMM00417742 CHEMBL2331710 Bioactive N-[3-(5-amino-4-thia-6-azabicyclo[5.1.0]oct-5-en-7-yl)phenyl]-5-chloropyridine-2-carboxamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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