CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Progesterone receptor and Glucocorticoid receptor ligand (5Z)-9-fluoro-2,2,4-trimethyl-5-[(3-methylpyridin-4-yl)methylidene]-1H-chromeno[3,4-f]quinoline family
No. of Seeds 5 No. of Other Members 2
Family Centroid CFAMM00307709 Functional Category Bioactive
Superfamily Beta-secretase 1 and Progesterone receptor Binder Superfamily
Class Class 970

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
DNA Binder Elliptinium Acetate Family 11 116
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 5 40
5-hydroxytryptamine receptor 2C and Cytochrome P450 1A2 ligand... 6 4
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 3
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Corticotropin-releasing factor receptor 1 ligand 3-ethyl-1-(2-... 5 15
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
Protein kinase C theta type and Protein kinase C delta type in... 10 7
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 2


External ID

Functional Category

Molecule Name

CFAMM00307703 CHEMBL132363 Bioactive (5Z)-9-fluoro-2,2,4-trimethyl-5-[(3-methylpyridin-2-yl)methylidene]-1H-chromeno[3,4-f]quinoline
CFAMM00307709 CHEMBL130141 Bioactive (5Z)-9-fluoro-2,2,4-trimethyl-5-[(3-methylpyridin-4-yl)methylidene]-1H-chromeno[3,4-f]quinoline
CFAMM00307708 CHEMBL335879 Bioactive (5Z)-9-fluoro-2,2,4-trimethyl-5-(pyridin-2-ylmethylidene)-1H-chromeno[3,4-f]quinoline
CFAMM00307707 CHEMBL336751 Bioactive (5Z)-9-fluoro-2,2,4-trimethyl-5-(pyridin-4-ylmethylidene)-1H-chromeno[3,4-f]quinoline
CFAMM00307706 CHEMBL102179 Bioactive 5-(6-bromopyridin-3-yl)-2,2,4-trimethyl-1,5-dihydrochromeno[3,4-f]quinoline

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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