CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12703
Family Name NAD-dependent protein deacetylase sirtuin-2 and NAD-dependent protein deacetylase sirtuin-1 inhibitor 2-N-[2-[1-(6-carbamoylthieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl]ethyl]-5-N-ethylthiophene-2,5-dicarboxamide family
No. of Seeds 8 No. of Other Members 12
Family Centroid CFAMM00417789 Functional Category Bioactive
Superfamily NAD-dependent protein deacetylase sirtuin-2 and Huntingtin Binder Superfamily
Class Class 3131

Cousin Family NamesSeedsMembers
Abelson tyrosine-protein kinase 2 inhibitor thiazole derivativ... 19 50
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Omega 1 Benzodiazepine receptor Ligand Indiplon Family 4 25
JAK Inhibitor Momelotinib Family 33 83
Histone deacetylase 1 Inhibitor N-hydroxy-5-(pyridin-3-yl)thio... 9 46
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Rho-associated protein kinase 2 and cAMP-dependent protein kin... 3 5
Adenosine receptor A2b and Adenosine receptor A2a ligand SureC... 1 26
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-(4... 3 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-07ZDR2 f... 7 33
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
Serine/threonine-protein kinase Chk1 inhibitor SureCN13010134 ... 7 29
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Serine/threonine-protein kinase Chk1 inhibitor 2-(1-methylindo... 3 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 8 1
Thyroid hormone receptor beta and Ferritin light chain ligand ... 3 10
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QJ7P family 2 0
Neuronal acetylcholine receptor subunit alpha-7 ligand AGN-PC-... 7 1
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 8 5
Protein kinase C zeta type and Inhibitor of nuclear factor kap... 1 6
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 15 8
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Cell division cycle 7-related protein kinase and Protein DBF4 ... 1 0
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
cAMP-dependent protein kinase catalytic subunit beta and cAMP-... 2 9
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 5 0
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
NAD-dependent protein deacetylase sirtuin-2 and NAD-dependent ... 2 0
Melanocortin receptor 4 ligand AGN-PC-076ANF family 1 0
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(6-morp... 2 0
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-074MSE family 18 2
Tyrosine-protein kinase Lck inhibitor AGN-PC-074MPV family 4 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-03HL8Q family 4 0
Adenosine receptor A2a and Adenosine receptor A1 ligand [2-(2-... 2 9
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 20 7
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-00A4QJ family 12 6
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 5 1
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 5 0
Adenosine receptor A2a and Adenosine receptor A1 ligand thioph... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00417789 CHEMBL2332039 Bioactive 2-N-[2-[1-(6-carbamoylthieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl]ethyl]-5-N-ethylthiophene-2,5-dicarboxamide
CFAMM00417802 CHEMBL2332044 Bioactive tert-butyl N-[2-[1-(6-carbamoylthieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl]ethyl]carbamate
CFAMM00417801 CHEMBL2332043 Bioactive 4-[4-[2-(thiophene-2-carbonylamino)ethyl]piperidin-1-yl]thieno[3,2-d]pyrimidine-6-carboxamide
CFAMM00417792 CHEMBL2338810 Bioactive 4-[4-[2-(methanesulfonamido)ethyl]piperidin-1-yl]thieno[3,2-d]pyrimidine-6-carboxamide
CFAMM00417807 CHEMBL2332055 Bioactive 4-[4-[2-(2,2-dimethylpropanoylamino)ethyl]piperidin-1-yl]thieno[3,2-d]pyrimidine-6-carboxamide
CFAMM00417799 CHEMBL2332040 Bioactive 2-N-[2-[4-(6-carbamoylthieno[3,2-d]pyrimidin-4-yl)piperazin-1-yl]ethyl]-5-N-ethylthiophene-2,5-dicarboxamide
CFAMM00417790 CHEMBL2332037 Bioactive 3-N-[2-[1-(6-carbamoylthieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl]ethyl]-1-N-ethylbenzene-1,3-dicarboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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