CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12708
Family Name Sodium-dependent serotonin transporter and D(2) dopamine receptor ligand 1-[2-[(2R)-4-(6-fluoronaphthalen-1-yl)-2-methylpiperazin-1-yl]ethyl]-3,4-dihydro-1H-isochromene-6-carboxamide family
No. of Seeds 8 No. of Other Members 6
Family Centroid CFAMM00417843 Functional Category Bioactive
Superfamily Progesterone receptor and D(2) dopamine receptor Binder Superfamily 3
Class Class 2499

Cousin Family NamesSeedsMembers
Sodium channel protein type 10 subunit alpha Ligand Tetracaine... 6 166
Histone deacetylase 1 and Tyrosine-protein kinase JAK2 Inhibit... 2 3
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Kinesin-like protein KIF11 Inhibitor EMD-534085 Family 2 26
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Retinal dehydrogenase 1 and Menin inhibitor CHEMBL1507858 family 1 6
Neuropeptide Y receptor type 5 ligand SureCN3382773 family 1 13
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 0
Retinoic acid receptor beta and Retinoic acid receptor gamma l... 4 7
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Histone deacetylase 1 and Histone deacetylase 2 inhibitor Sure... 1 4
Multidrug resistance protein 1 inhibitor [(2R,3S,4R)-4-[[(2S)-... 1 5
NP Methyl 3-acetyl-4-oxo-1,4-dihydroquinoline-8-carboxylate Fa... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00417850 CHEMBL391272 Bioactive (1S)-1-[2-[(2S)-4-(6-fluoronaphthalen-2-yl)-2-methylpiperazin-1-yl]ethyl]-3,4-dihydro-1H-isochromene-6-carboxamide
CFAMM00417843 CHEMBL234447 Bioactive 1-[2-[(2R)-4-(6-fluoronaphthalen-1-yl)-2-methylpiperazin-1-yl]ethyl]-3,4-dihydro-1H-isochromene-6-carboxamide
CFAMM00417849 CHEMBL391273 Bioactive SureCN6812759
CFAMM00417842 CHEMBL234449 Bioactive SureCN6808258
CFAMM00417848 CHEMBL391271 Bioactive SureCN6811543
CFAMM00417841 CHEMBL234448 Bioactive (1R)-1-[2-[(2R)-4-(6-fluoronaphthalen-1-yl)-2-methylpiperazin-1-yl]ethyl]-3,4-dihydro-1H-isochromene-6-carboxamide
CFAMM00417853 CHEMBL441095 Bioactive PNU-142633
CFAMM00417852 CHEMBL233210 Bioactive (1S)-1-[2-[(2S)-4-(6-cyanonaphthalen-1-yl)-2-methylpiperazin-1-yl]ethyl]-3,4-dihydro-1H-isochromene-6-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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