CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12720
Family Name Integrin beta-1 and Integrin alpha-4 inhibitor 4-[[(2S,5S)-5-(ethoxymethyl)-1-[2-[7-fluoro-2-(5-fluoro-2-methylanilino)-1,3-benzoxazol-6-yl]acetyl]pyrrolidin-2-yl]methoxy]cyclohexane-1-carboxylic acid family
No. of Seeds 20 No. of Other Members 10
Family Centroid CFAMM00417897 Functional Category Bioactive
Superfamily Integrin alpha-4 and Cathepsin S Binder Superfamily
Class Class 678

Cousin Family NamesSeedsMembers
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Peroxisome proliferator-activated receptor gamma Ligand SB-213... 2 54
Vascular endothelial growth factor receptor 1 and Vascular end... 4 44
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
Arachidonate 5-lipoxygenase Inhibitor 5-methyl-n-phenylbenzo[d... 5 13
Somatostatin receptor type 5 and Potassium voltage-gated chann... 2 21
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(2-oxo-3... 2 11
5-hydroxytryptamine receptor 3A ligand 2-[(3S)-3-ethylmorpholi... 10 18
Prelamin-A/C inhibitor CHEMBL1374443 family 1 6
Integrin beta-1 and Integrin alpha-4 inhibitor 4-[[(2S,4S)-4-f... 4 7
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S,... 2 3
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 14 24
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-[4-(1,3-benzoxazol... 3 4
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 1
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 5 2
Cathepsin S and Cathepsin L1 inhibitor (2S)-2-(1,3-benzoxazol-... 1 9
Cathepsin S and Cathepsin L1 inhibitor SureCN5361439 family 2 4
Integrin alpha-4 inhibitor (5R)-5-[[(2R)-2-[[2-[4-(1,3-benzoxa... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor 4-[[(2S,4S)-1-[... 2 0
Somatostatin receptor type 5 ligand SureCN3572493 family 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00417893 CHEMBL2332699 Bioactive 4-[[(2S,5S)-1-[2-[7-fluoro-2-(5-fluoro-2-methylanilino)-1,3-benzoxazol-6-yl]acetyl]-5-(1,2-oxazolidin-2-ylmethyl)pyrrolidin-2-yl]methoxy]cyclohexane-1-carboxylic acid
CFAMM00417921 CHEMBL2332705 Bioactive 4-[[(2S,5S)-1-[2-[7-fluoro-2-(5-fluoro-2-methylanilino)-1,3-benzoxazol-6-yl]acetyl]-5-(methoxymethyl)pyrrolidin-2-yl]methoxy]cyclohexane-1-carboxylic acid
CFAMM00417899 CHEMBL2332692 Bioactive 4-[[(2S,5S)-1-[2-[7-fluoro-2-(5-fluoro-2-methylanilino)-1,3-benzoxazol-6-yl]acetyl]-5-(hydroxymethyl)pyrrolidin-2-yl]methoxy]cyclohexane-1-carboxylic acid
CFAMM00417906 CHEMBL584081 Bioactive 4-[[(2S,4S)-4-fluoro-1-[2-[7-fluoro-2-(5-fluoro-2-methylanilino)-1,3-benzoxazol-6-yl]acetyl]pyrrolidin-2-yl]methoxy]cyclohexane-1-carboxylic acid
CFAMM00417920 CHEMBL2332706 Bioactive 4-[[(2S,5S)-1-[2-[7-fluoro-2-(2-methylanilino)-1,3-benzoxazol-6-yl]acetyl]-5-(methoxymethyl)pyrrolidin-2-yl]methoxy]cyclohexane-1-carboxylic acid
CFAMM00417898 CHEMBL2332693 Bioactive 4-[[(2S,5R)-1-[2-[7-fluoro-2-(5-fluoro-2-methylanilino)-1,3-benzoxazol-6-yl]acetyl]-5-methylpyrrolidin-2-yl]methoxy]cyclohexane-1-carboxylic acid
CFAMM00417904 CHEMBL481501 Bioactive SureCN14592120
CFAMM00417919 CHEMBL2332700 Bioactive 4-[[(2S,5S)-1-[2-[7-fluoro-2-(5-fluoro-2-methylanilino)-1,3-benzoxazol-6-yl]acetyl]-5-(morpholin-4-ylmethyl)pyrrolidin-2-yl]methoxy]cyclohexane-1-carboxylic acid
CFAMM00417897 CHEMBL2332690 Bioactive 4-[[(2S,5S)-5-(ethoxymethyl)-1-[2-[7-fluoro-2-(5-fluoro-2-methylanilino)-1,3-benzoxazol-6-yl]acetyl]pyrrolidin-2-yl]methoxy]cyclohexane-1-carboxylic acid
CFAMM00417903 CHEMBL2332696 Bioactive 4-[[(2S,5S)-1-[2-[7-fluoro-2-(5-fluoro-2-methylanilino)-1,3-benzoxazol-6-yl]acetyl]-5-(methylsulfonylmethyl)pyrrolidin-2-yl]methoxy]cyclohexane-1-carboxylic acid
CFAMM00417918 CHEMBL2332701 Bioactive 4-[[(2S,5S)-1-[2-[7-fluoro-2-(5-fluoro-2-methylanilino)-1,3-benzoxazol-6-yl]acetyl]-5-[(3-methoxyazetidin-1-yl)methyl]pyrrolidin-2-yl]methoxy]cyclohexane-1-carboxylic acid
CFAMM00417896 CHEMBL2332691 Bioactive 4-[[(2S,5S)-5-(ethoxymethyl)-1-[2-[7-fluoro-2-(2-methylanilino)-1,3-benzoxazol-6-yl]acetyl]pyrrolidin-2-yl]methoxy]cyclohexane-1-carboxylic acid
CFAMM00417902 CHEMBL2332697 Bioactive 4-[[(2S,5S)-5-[(dimethylamino)methyl]-1-[2-[7-fluoro-2-(5-fluoro-2-methylanilino)-1,3-benzoxazol-6-yl]acetyl]pyrrolidin-2-yl]methoxy]cyclohexane-1-carboxylic acid
CFAMM00417901 CHEMBL2332694 Bioactive 4-[[(2S,5S)-1-[2-[7-fluoro-2-(5-fluoro-2-methylanilino)-1,3-benzoxazol-6-yl]acetyl]-5-(fluoromethyl)pyrrolidin-2-yl]methoxy]cyclohexane-1-carboxylic acid
CFAMM00417916 CHEMBL2332703 Bioactive 4-[[(2R,3R)-1-[2-[7-fluoro-2-(5-fluoro-2-methylanilino)-1,3-benzoxazol-6-yl]acetyl]-3-methoxypyrrolidin-2-yl]methoxy]cyclohexane-1-carboxylic acid
CFAMM00417894 CHEMBL2332698 Bioactive 4-[[(2S,5S)-1-[2-[7-fluoro-2-(5-fluoro-2-methylanilino)-1,3-benzoxazol-6-yl]acetyl]-5-[[methoxy(methyl)amino]methyl]pyrrolidin-2-yl]methoxy]cyclohexane-1-carboxylic acid
CFAMM00417908 CHEMBL571944 Bioactive 4-[[(2S,4S)-4-fluoro-1-[2-[7-fluoro-2-(2-methylanilino)-1,3-benzoxazol-6-yl]acetyl]pyrrolidin-2-yl]methoxy]cyclohexane-1-carboxylic acid
CFAMM00417922 CHEMBL2332704 Bioactive 4-[[(2S,5R)-1-[2-[7-fluoro-2-(5-fluoro-2-methylanilino)-1,3-benzoxazol-6-yl]acetyl]-5-(methoxymethyl)pyrrolidin-2-yl]methoxy]cyclohexane-1-carboxylic acid
CFAMM00417900 CHEMBL2332695 Bioactive 4-[[(2S,5S)-1-[2-[7-fluoro-2-(5-fluoro-2-methylanilino)-1,3-benzoxazol-6-yl]acetyl]-5-(methylsulfanylmethyl)pyrrolidin-2-yl]methoxy]cyclohexane-1-carboxylic acid
CFAMM00417915 CHEMBL572174 Bioactive 4-[[(2S,4S)-4-fluoro-1-[2-[2-(5-fluoro-2-methylanilino)-1,3-benzoxazol-6-yl]acetyl]pyrrolidin-2-yl]methoxy]cyclohexane-1-carboxylic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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