CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12725
Family Name Leucine-rich repeat serine/threonine-protein kinase 2 inhibitor 4-[[(1R)-1-cyclopropylethyl]amino]-7-pyridin-4-ylcinnoline-3-carboxamide family
No. of Seeds 2 No. of Other Members 3
Family Centroid CFAMM00417944 Functional Category Bioactive
Superfamily TGF-beta receptor type-1 Ligand LY2157299 Superfamily
Class Class 1276

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
HIV protease Inhibitor Saquinavir Family 64 428
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
Hepatocyte growth factor receptor Ligand MK-8033 Family 19 42
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
CP-18770 family 6 27
JAK Inhibitor Momelotinib Family 33 83
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-chlorophenyl)-5-... 2 8
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 5 10
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Adenosine receptor A3 Ligand 2-phenyl-2h-pyrazolo[4,3-d]pyrimi... 2 7
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Glutamate receptor 1 Ligand Piriqualone Family 8 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Metabotropic glutamate receptor 1 Ligand N-(2-phenylpropyl)qui... 3 1
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Orexin receptor type 2 and Orexin receptor type 1 ligand AGN-P... 7 19
5-hydroxytryptamine receptor 2A ligand AGN-PC-04RTMN family 7 5
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... 6 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M8RE fa... 6 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07PRSG fa... 6 0
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 1
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Serine/threonine-protein kinase 17A and Myosin light chain kin... 3 7
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
Hepatocyte growth factor receptor ligand 9-[[3-methoxypropyl(m... 17 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 1
Cannabinoid receptor 1 ligand N-[1-[[(1R)-1-[4-(3-chloroindazo... 10 0
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
cAMP-dependent protein kinase catalytic subunit PRKX and Rho-a... 1 1
Hepatocyte growth factor receptor ligand 5-(3-methyl-1,2-thiaz... 5 2
5-hydroxytryptamine receptor 4 ligand N-[(1R,5S)-8-[2-hydroxy-... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 2 3
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Cannabinoid receptor 1 ligand N-(cyclobutylmethyl)-3-[[4-(meth... 1 1
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand N-(oxan-... 2 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 1 0
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Motilin receptor ligand SureCN2768052 family 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 6-(b... 5 5
Cannabinoid receptor 1 ligand AGN-PC-07R6QU family 4 2
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Histone deacetylase 1 inhibitor AGN-PC-0456JP family 1 0
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R6UP family 2 0
Tyrosine-protein kinase receptor TYRO3 ligand 3-amino-6-(1H-in... 2 3
Cyclin-dependent kinase 2 inhibitor N-[(4-chlorophenyl)carbamo... 7 2
Vascular endothelial growth factor receptor 2 and Vascular end... 5 9


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00417944 CHEMBL2333113 Bioactive 4-[[(1R)-1-cyclopropylethyl]amino]-7-pyridin-4-ylcinnoline-3-carboxamide
CFAMM00417943 CHEMBL2333118 Bioactive 7-(1-methylpyrazol-4-yl)-4-(propan-2-ylamino)cinnoline-3-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24530 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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