CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12726
Family Name Leucine-rich repeat serine/threonine-protein kinase 2 inhibitor 4-(propan-2-ylamino)-6-(1H-pyrazol-4-yl)cinnoline-3-carboxamide family
No. of Seeds 1 No. of Other Members 1
Family Centroid CFAMM00417949 Functional Category Bioactive
Superfamily Leucine-rich repeat serine/threonine-protein kinase 2 and Orexin receptor type 1 Binder Superfamily
Class Class 208

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Cyclin-dependent kinase 2 Inhibitor AT7519 Family 2 14
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
D(3) dopamine receptor Ligand SB-277011 Family 13 178
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Aurora kinase B and Aurora kinase C Inhibitor PHA-680632 Family 5 72
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 5 10
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 19 12
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 3
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M8RE fa... 6 1
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 29
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
5-hydroxytryptamine receptor 3A ligand SureCN8035577 family 5 4
Serine/threonine-protein kinase 17A and Myosin light chain kin... 3 7
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 1
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor SBC family 5 18
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 3 5
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-075CD... 2 8
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 18
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 4 3
cAMP-dependent protein kinase catalytic subunit PRKX and Rho-a... 1 1
Calcitonin gene-related peptide type 1 receptor ligand 2-[(7-m... 3 0
Calcitonin gene-related peptide type 1 receptor ligand 3-[1-[4... 5 3
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 5 3
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 3
Leucine-rich repeat serine/threonine-protein kinase 2 and Macr... 1 0
Rho-associated protein kinase 2 inhibitor 2-[(3S,4R)-4-(4-fluo... 9 0
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 4 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN4298966 f... 10 1
Serine/threonine-protein kinase Chk1 inhibitor 5-[(2S)-3-amino... 4 6
Serine/threonine-protein kinase Chk1 inhibitor PDK1 inhibitor,... 1 4
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 0
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
Serine/threonine-protein kinase D1 inhibitor 3-[5-[3-bromo-4-(... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00417949 CHEMBL2333115 Bioactive 4-(propan-2-ylamino)-6-(1H-pyrazol-4-yl)cinnoline-3-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26843 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543