CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12729
Family Name cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN4989397 family
No. of Seeds 9 No. of Other Members 2
Family Centroid CFAMM00417974 Functional Category Bioactive
Superfamily D(2) dopamine receptor and Methionine--tRNA ligase Binder Superfamily
Class Class 409

Cousin Family NamesSeedsMembers
Histamine N-methyltransferase inhibitor aminoquinoline Amodiaq... 8 23
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 67 130
Dihydroorotate dehydrogenase Inhibitor LY214352 Family 2 17
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Vascular endothelial growth factor receptor 2 and Vascular end... 3 3
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS5MA ... 3 4
Proto-oncogene tyrosine-protein kinase Src inhibitor AGN-PC-07... 17 9
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS94Q ... 6 0
Histidine-rich protein PFHRP-II inhibitor AGN-PC-075SYG family 1 0


External ID

Functional Category

Molecule Name

CFAMM00417966 CHEMBL2333223 Bioactive 4-[(3-chloro-4-methoxyphenyl)methylamino]-8-(cyclopropylamino)-3-(hydroxymethyl)quinoline-6-carbonitrile
CFAMM00417972 CHEMBL291127 Bioactive SureCN4990308
CFAMM00417965 CHEMBL2333224 Bioactive 4-[(3-chloro-4-methoxyphenyl)methylamino]-3-(hydroxymethyl)-8-morpholin-4-ylquinoline-6-carbonitrile
CFAMM00417964 CHEMBL41236 Bioactive SureCN4990877
CFAMM00417970 CHEMBL38735 Bioactive SureCN4997159
CFAMM00417969 CHEMBL2333220 Bioactive 4-[(3-chloro-4-methoxyphenyl)methylamino]-8-(dimethylamino)-3-(hydroxymethyl)quinoline-6-carbonitrile
CFAMM00417968 CHEMBL2333221 Bioactive 4-[(3-chloro-4-methoxyphenyl)methylamino]-8-[2-(dimethylamino)ethylamino]-3-(hydroxymethyl)quinoline-6-carbonitrile
CFAMM00417974 CHEMBL289047 Bioactive SureCN4989397
CFAMM00417973 CHEMBL2333219 Bioactive 4-[(3-chloro-4-methoxyphenyl)methylamino]-8-cyclopropyl-3-(hydroxymethyl)quinoline-6-carbonitrile

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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