CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12745
Family Name Substance-P receptor and Sodium-dependent serotonin transporter ligand 2-[[4-(4-fluorophenyl)-1-methylpiperidin-4-yl]methoxymethyl]-6-(2-methylcyclopropyl)-4-(trifluoromethyl)pyridine family
No. of Seeds 11 No. of Other Members 6
Family Centroid CFAMM00418011 Functional Category Bioactive
Superfamily Substance-P receptor and Nitric oxide synthase, brain Binder Superfamily
Class Class 2845

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Doxylamine Family 2 91
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Squalene synthase Inhibitor ER-119884 Family 2 3
Substance-P receptor ligand 1-[4-[[3,5-bis(trifluoromethyl)phe... 3 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 15
Growth hormone secretagogue receptor type 1 ligand SureCN62436... 8 6
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Sodium-dependent serotonin transporter and Substance-P recepto... 4 1
Substance-P receptor and Sodium-dependent serotonin transporte... 11 4
Sodium-dependent serotonin transporter and Substance-P recepto... 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Nociceptin receptor and Potassium voltage-gated channel subfam... 3 9
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00418018 CHEMBL2333608 Bioactive 2-(1-fluorocyclopropyl)-6-[[4-(4-fluorophenyl)-1-methylpiperidin-4-yl]methoxymethyl]-4-(trifluoromethyl)pyridine
CFAMM00418011 CHEMBL2333606 Bioactive 2-[[4-(4-fluorophenyl)-1-methylpiperidin-4-yl]methoxymethyl]-6-(2-methylcyclopropyl)-4-(trifluoromethyl)pyridine
CFAMM00418024 CHEMBL2333615 Bioactive 2-cyclopropyl-6-[[4-(3-fluorophenyl)-1-methylpiperidin-4-yl]methoxymethyl]-4-(trifluoromethyl)pyridine
CFAMM00418023 CHEMBL2333632 Bioactive 2-[[4-(4-fluorophenyl)-1-methylpiperidin-4-yl]methoxymethyl]-6-methoxy-4-(trifluoromethyl)pyridine
CFAMM00418022 CHEMBL2333631 Bioactive 6-[(1-methyl-4-phenylpiperidin-4-yl)methoxymethyl]-4-(trifluoromethyl)pyridine-2-carbonitrile
CFAMM00418015 CHEMBL2333607 Bioactive 2-(2,2-dimethylcyclopropyl)-6-[[4-(4-fluorophenyl)-1-methylpiperidin-4-yl]methoxymethyl]-4-(trifluoromethyl)pyridine
CFAMM00418021 CHEMBL2333637 Bioactive 2-cyclopropyl-6-[[4-(4-fluorophenyl)-1-methylpiperidin-4-yl]methoxymethyl]-4-(trifluoromethyl)pyridine
CFAMM00418027 CHEMBL2333611 Bioactive 2,4-dicyclopropyl-6-[[4-(4-fluorophenyl)-1-methylpiperidin-4-yl]methoxymethyl]pyridine
CFAMM00418013 CHEMBL2333605 Bioactive 2-cyclopropyl-6-[(4-phenylpiperidin-4-yl)methoxymethyl]-4-(trifluoromethyl)pyridine
CFAMM00418026 CHEMBL2333610 Bioactive 2-cyclopentyl-6-[[4-(4-fluorophenyl)-1-methylpiperidin-4-yl]methoxymethyl]-4-(trifluoromethyl)pyridine
CFAMM00418025 CHEMBL2333612 Bioactive 2-cyclopropyl-6-[[4-(4-fluorophenyl)-1-methylpiperidin-4-yl]methoxymethyl]pyridine-4-carbonitrile

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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