CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12752
Family Name P2Y purinoceptor 1 inhibitor 1-(4-tert-butylphenyl)-3-[2-(2-propan-2-ylphenoxy)pyridin-3-yl]urea family
No. of Seeds 4 No. of Other Members 14
Family Centroid CFAMM00418058 Functional Category Bioactive
Superfamily Cationic trypsin and P2Y purinoceptor 1 Binder Superfamily
Class Class 963

Cousin Family NamesSeedsMembers
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Cannabinoid receptor 1 Ligand Taranabant Family 20 30
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 31
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 50 36
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Transient receptor potential cation channel subfamily V member... 2 12
Transient receptor potential cation channel subfamily V member... 2 1
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
5-hydroxytryptamine receptor 2C and Cytochrome P450 1A2 ligand... 6 4
Fatty-acid amide hydrolase 1 and Cytochrome P450 2D6 inhibitor... 2 0
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 24 5
Beta-1 adrenergic receptor ligand 1-[2-[[(2S)-3-(2-cyanophenox... 4 1
Cholesteryl ester transfer protein inhibitor 1-[(1S)-1-(5-chlo... 11 8
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 2 7
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 3
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Transient receptor potential cation channel subfamily V member... 6 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
Mitogen-activated protein kinase 9 and Tyrosine-protein kinase... 2 6
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Bifunctional epoxide hydrolase 2 and Voltage-dependent L-type ... 2 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 25 0
Acyl-CoA:cholesterol acyltransferase inhibitor 3-(2-chloro-6-m... 4 6
Transient receptor potential cation channel subfamily V member... 3 2
Transient receptor potential cation channel subfamily V member... 2 3
Coagulation factor X and Cationic trypsin inhibitor SureCN6578... 4 11


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00418058 CHEMBL2333772 Bioactive 1-(4-tert-butylphenyl)-3-[2-(2-propan-2-ylphenoxy)pyridin-3-yl]urea
CFAMM00418057 CHEMBL2333770 Bioactive 1-[2-(2-tert-butylphenoxy)pyridin-3-yl]-3-[4-(trifluoromethoxy)phenyl]urea
CFAMM00418052 CHEMBL2381888 Bioactive methyl 1-[4-[[2-(2-tert-butylphenoxy)pyridin-3-yl]carbamoylamino]phenyl]cyclopropane-1-carboxylate
CFAMM00418045 CHEMBL2381894 Bioactive 1-[4-(4-benzylpiperazin-1-yl)phenyl]-3-[2-(2-tert-butylphenoxy)pyridin-3-yl]urea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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