CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12757
Family Name Rho-associated protein kinase 2 inhibitor 2-[(1S)-1-amino-2-(4-chlorophenyl)ethyl]-6-(1H-pyrazol-4-yl)-1H-quinazolin-4-one family
No. of Seeds 6 No. of Other Members 10
Family Centroid CFAMM00418086 Functional Category Bioactive
Superfamily Rho-associated protein kinase 2 and Nonstructural protein 1 Binder Superfamily
Class Class 1276

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Rho-associated protein kinase 2 inhibitor 2-[(3S,4R)-4-(4-fluo... 9 0
Rho-associated protein kinase 1 and Ribosomal protein S6 kinas... 4 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00418080 CHEMBL2333893 Bioactive 2-[amino-(4-chlorophenyl)methyl]-6-(1H-pyrazol-4-yl)-1H-quinazolin-4-one
CFAMM00418086 CHEMBL2334293 Bioactive 2-[(1S)-1-amino-2-(4-chlorophenyl)ethyl]-6-(1H-pyrazol-4-yl)-1H-quinazolin-4-one
CFAMM00418085 CHEMBL2334294 Bioactive 2-[(1R)-1-amino-2-(4-chlorophenyl)ethyl]-6-(1H-pyrazol-4-yl)-1H-quinazolin-4-one
CFAMM00418082 CHEMBL2333882 Bioactive N-[(4-chlorophenyl)-[4-oxo-6-(1H-pyrazol-4-yl)-1H-quinazolin-2-yl]methyl]-2-(dimethylamino)acetamide
CFAMM00418081 CHEMBL2333883 Bioactive 3-amino-N-[(4-chlorophenyl)-[4-oxo-6-(1H-pyrazol-4-yl)-1H-quinazolin-2-yl]methyl]propanamide
CFAMM00418074 CHEMBL2333898 Bioactive 2-[(3S,4R)-4-(4-chlorophenyl)pyrrolidin-3-yl]-6-(1H-pyrazol-4-yl)-1H-quinazolin-4-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26848 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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