CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12758
Family Name Rho-associated protein kinase 2 inhibitor 2-[(3S,4R)-4-(4-fluorophenyl)pyrrolidin-3-yl]-6-(1H-pyrazol-4-yl)-1H-quinazolin-4-one family
No. of Seeds 9 No. of Other Members 0
Family Centroid CFAMM00418093 Functional Category Bioactive
Superfamily Rho-associated protein kinase 2 and Nonstructural protein 1 Binder Superfamily
Class Class 1276

Cousin Family NamesSeedsMembers
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Mitogen-activated protein kinase 14 and Mast/stem cell growth ... 4 4
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 3
Serine/threonine-protein kinase 17A and Myosin light chain kin... 3 7
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 3 5
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-075CD... 2 8
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 18
cAMP-dependent protein kinase catalytic subunit PRKX and Rho-a... 1 1
Calcitonin gene-related peptide type 1 receptor ligand 2-[(7-m... 3 0
Rho-associated protein kinase 1 and Ribosomal protein S6 kinas... 4 5
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 1
Rho-associated protein kinase 2 inhibitor 2-[(1S)-1-amino-2-(4... 6 10
Platelet-derived growth factor receptor beta and Ribosomal pro... 1 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 4 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN4298966 f... 10 1
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 0
Rho-associated protein kinase 1 and Ribosomal protein S6 kinas... 4 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00418089 CHEMBL2333914 Bioactive 2-[(1R)-1-amino-2-(3-fluorophenyl)ethyl]-6-(1H-pyrazol-4-yl)-1H-quinazolin-4-one
CFAMM00418095 CHEMBL2334291 Bioactive 6-(5-methyl-1H-pyrazol-4-yl)-2-[(3S,4R)-4-phenylpyrrolidin-3-yl]-1H-quinazolin-4-one
CFAMM00418088 CHEMBL2333912 Bioactive 2-[(1R)-1-amino-2-(3,4-difluorophenyl)ethyl]-6-(1H-pyrazol-4-yl)-1H-quinazolin-4-one
CFAMM00418094 CHEMBL2334292 Bioactive 2-[(3S,4R)-4-phenylpyrrolidin-3-yl]-6-(1H-pyrazol-4-yl)-1H-quinazolin-4-one
CFAMM00418093 CHEMBL2333897 Bioactive 2-[(3S,4R)-4-(4-fluorophenyl)pyrrolidin-3-yl]-6-(1H-pyrazol-4-yl)-1H-quinazolin-4-one
CFAMM00418092 CHEMBL2333899 Bioactive 6-(1H-pyrazol-4-yl)-2-[(3S,4R)-4-[4-(trifluoromethyl)phenyl]pyrrolidin-3-yl]-1H-quinazolin-4-one
CFAMM00418091 CHEMBL2333906 Bioactive 2-[(1R)-1-amino-2-(4-fluorophenyl)ethyl]-6-(1H-pyrazol-4-yl)-1H-quinazolin-4-one
CFAMM00418090 CHEMBL2333886 Bioactive 2-[(3S,4R)-1,1-dimethyl-4-phenylpyrrolidin-1-ium-3-yl]-6-(1H-pyrazol-4-yl)-1H-quinazolin-4-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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