CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12773
Family Name Melanocortin receptor 4 ligand AGN-PC-076AMT family
No. of Seeds 2 No. of Other Members 9
Family Centroid CFAMM00418180 Functional Category Bioactive with Natural Product
Superfamily Beta-lactamase and Histamine H3 receptor Binder Superfamily 8
Class Class 4935

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Prothrombin Inhibitor Dabigatran Family 7 182
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
BIBT986 family 7 96
SB989 family 17 91
CC-486 family 7 103
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) ... 9 93
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
Acetylcholinesterase inhibitor SureCN251059 family 2 16
Mitogen-activated protein kinase 14 inhibitor DEL-B, 14b family 2 0
Cannabinoid receptor 2 ligand AGN-PC-080WIY family 1 0
Adenosine receptor A2a ligand AGN-PC-01LVXW family 2 25
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 2 9
Poly [ADP-ribose] polymerase 1 inhibitor ethyl 4-(4-carbamoyl-... 2 15
Thyroid hormone receptor beta ligand CHEMBL1325165 family 1 6
Poly [ADP-ribose] polymerase 1 inhibitor SureCN6202744 family 4 2
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 1
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
Bile acid receptor ligand 4-[[(2S)-2-[2-(4-chlorophenyl)-5,6-d... 4 12
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 10 14
Histamine H3 receptor and Potassium voltage-gated channel subf... 7 1
Histamine H3 receptor ligand SureCN2878688 family 8 1
Scavenger receptor class B member 1 ligand methyl 9-[3-(4,6-di... 2 10
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
Delta-type opioid receptor ligand ethyl N-[3-[(R)-[4-[ethyl(me... 2 6
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 4 29
Neuropeptide Y receptor type 5 ligand AGN-PC-07R6YQ family 7 7
Neuropeptide Y receptor type 5 ligand SureCN4170426 family 4 13
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
Coagulation factor X inhibitor AGN-PC-07C10A family 3 2
Cdc2-related kinase inhibitor N-[6-(3,5-dimethylphenyl)-1-meth... 1 0
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 2 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 10 1
Disintegrin and metalloproteinase domain-containing protein 17... 3 0
Disintegrin and metalloproteinase domain-containing protein 17... 10 4
Integrin beta-3 and Integrin alpha-V inhibitor 2-[1-[2-[[4-(1H... 2 8
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 0
Histamine H3 receptor ligand AGN-PC-075YVW family 1 2
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
Cell division cycle 7-related protein kinase inhibitor Pyrrolo... 2 6
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RDJ family 15 1
5-hydroxytryptamine receptor 2B ligand SureCN1299002 family 2 8
Neuropeptide Y receptor type 5 ligand 1'-(5-CHLORO-1H-BENZIMID... 4 1
Neuropeptide Y receptor type 5 ligand AGN-PC-02WBQH family 7 1
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RCV family 2 1
Neuropeptide Y receptor type 5 ligand AGN-PC-077LX1 family 8 1
Dipeptidyl peptidase 4 inhibitor SureCN5776796 family 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07C5JC family 1 3
Neuropeptide Y receptor type 5 ligand SureCN8149543 family 1 0
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 5
Tyrosine-protein kinase Lck inhibitor AGN-PC-074LPB family 2 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-006EKH... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00418180 CHEMBL233559 Bioactive AGN-PC-076AMT
CFAMM00418181 CHEMBL40351 Bioactive methyl 2-[(1S)-1-[[(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl]amino]-3-methylbutyl]-3H-benzimidazole-5-carboxylate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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