CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12790
Family Name Prostaglandin E synthase inhibitor 3-[4-(3-cyanopropoxy)-3-methoxyphenyl]benzo[f]quinoline-1-carboxylic acid family
No. of Seeds 2 No. of Other Members 4
Family Centroid CFAMM00418306 Functional Category Bioactive with Natural Product
Superfamily Acetylcholinesterase Inhibitor Lysicamine Superfamily
Class Class 2976

Cousin Family NamesSeedsMembers
Cyclooxygenase Inhibitor Indomethacin Family 6 271
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Dihydroorotate dehydrogenase Inhibitor Brequinar Family 9 122
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Leukotriene B4 receptor 1 Ligand SB-201993 Family 5 13
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Metabotropic glutamate receptor 1 Ligand JNJ-16259685 Family 3 20
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
Prostaglandin E2 receptor EP1 subtype Ligand GSK-345931A Family 5 14
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Endothelin-1 receptor and Endothelin B receptor ligand (5S,6R,... 15 28
Neuromedin-K receptor and Substance-K receptor ligand 2-[2-phe... 2 2
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 18
Cysteinyl leukotriene receptor 2 and Cysteinyl leukotriene rec... 1 7
Cysteinyl leukotriene receptor 1 ligand 4-[(2S)-2-[[7-(quinoli... 6 15
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Cysteinyl leukotriene receptor 1 ligand SureCN7808360 family 4 11
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
Leukotriene B4 receptor 1 ligand SureCN8987110 family 8 20
Cellular tumor antigen p53 inhibitor CHEMBL1395699 family 1 30
B2 bradykinin receptor ligand SureCN6640854 family 7 4
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
NS5B protein inhibitor AGN-PC-00A17Z family 1 23
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 5 12
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Cysteinyl leukotriene receptor 1 and Peripheral myelin protein... 1 1
Prostaglandin D2 receptor and Prostaglandin E2 receptor EP2 su... 2 0
NS5B protein inhibitor AC1O5AET family 3 1
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 4
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 12 3
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[4... 7 4
Disintegrin and metalloproteinase domain-containing protein 17... 8 0
Insulin-like growth factor-binding protein 3 inhibitor (1E)-1-... 2 0
Cysteinyl leukotriene receptor 1 ligand 4-oxo-7-[[3-(quinolin-... 4 17
Prothrombin and Trypsin-1 inhibitor AGN-PC-074I4I family 3 1
Ras guanyl-releasing protein 3 and Protein kinase C alpha type... 2 6
Cysteinyl leukotriene receptor 1 ligand 2-[2-[5-[[3-[(E)-2-(6,... 1 8
Prothrombin inhibitor AGN-PC-074I2Z family 2 1
Cysteinyl leukotriene receptor 1 ligand 6-bromo-4-oxo-3-(quino... 3 1
Arachidonate 5-lipoxygenase inhibitor 4-(furan-3-yl)-7-[[5-(4-... 2 1
DNA polymerase beta and Microtubule-associated protein tau inh... 1 1
Potassium voltage-gated channel subfamily A member 3 ligand 7,... 2 36
Integrase and Serine/threonine-protein kinase pim-1 inhibitor ... 3 0
Potassium-transporting ATPase alpha chain 1 and Potassium-tran... 1 3
2-en-1-one NP (e)-3-(benzo[d][1,3]dioxol-5-yl)-1-(6-bromo-2-me... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00418306 CHEMBL2336518 Bioactive 3-[4-(3-cyanopropoxy)-3-methoxyphenyl]benzo[f]quinoline-1-carboxylic acid
CFAMM00418308 CHEMBL2385512 Bioactive 6-fluoro-2-(2-methyl-4-phenoxy-5-propan-2-ylphenyl)quinoline-4-carboxylic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27074 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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