CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12809
Family Name Type-1 angiotensin II receptor ligand 5-[2-[4-[[4-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-1-ium-1-yl]methyl]phenyl]phenyl]-2H-tetrazole;bromide family
No. of Seeds 4 No. of Other Members 2
Family Centroid CFAMM00418359 Functional Category Bioactive
Superfamily Type-1 angiotensin II receptor and Type-1B angiotensin II receptor Binder Superfamily
Class Class 3082

Cousin Family NamesSeedsMembers
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Type-1 angiotensin II receptor Ligand Losartan Family 3 90
Type-1 angiotensin II receptor Ligand Olmesartan Family 13 65
Type-1 angiotensin II receptor Ligand Forasartan Family 3 253
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
PF-4217903 family 14 65
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... 3 18
Aromatase and Thromboxane-A synthase Inhibitor 6-(1h-imidazol-... 3 8
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Type-2 angiotensin II receptor Ligand SC-50560 Family 3 84
Type-2 angiotensin II receptor Ligand SC-55634 Family 8 5
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 14 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Platelet-activating factor receptor ligand AGN-PC-0750SP family 4 0
Adenosine receptor A3 and Adenosine receptor A2a ligand SureCN... 8 7
Histamine H3 receptor ligand SureCN4025673 family 4 2
C-X-C chemokine receptor type 4 and Envelope glycoprotein gp16... 2 2
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 4 4
Serine/threonine-protein kinase B-raf inhibitor SureCN3495829 ... 24 0
Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 ... 8 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 27
Type-1B angiotensin II receptor ligand 2-[2-butyl-3-[[4-[2-(2H... 1 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 6
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 1 0
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14574... 1 2
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 9 6
Type-1B angiotensin II receptor ligand lithium;[2-butyl-5-chlo... 1 2
Type-1 angiotensin II receptor and Peroxisome proliferator-act... 6 0
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL1... 7 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 1 0
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... 2 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 5
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Adenosine receptor A1 ligand N-butyl-5-phenyl-3-[[2-(trifluoro... 7 2
Protein kinase C theta type and Protein kinase C delta type in... 9 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 2 0
ALK tyrosine kinase receptor ligand 3-[1-[(3-fluorophenyl)meth... 2 0
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 4 3
D(3) dopamine receptor and Muscarinic acetylcholine receptor M... 8 2
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 3 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor N-met... 2 1
Cathepsin K inhibitor 4-[2,2-dimethylpropyl-[[4-(1,2,4-triazol... 2 1
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 10 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 4
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 35 14
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 2 2
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 8 2
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 2 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 4 1
Type-1B angiotensin II receptor and Type-1 angiotensin II rece... 1 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 9 2
Corticotropin-releasing factor receptor 1 ligand SureCN7215846... 4 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 5 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 1
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 3 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 2 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 5
Type-1 angiotensin II receptor ligand 2-[(2-ethyl-5,7-dimethyl... 5 3
Type-1 angiotensin II receptor ligand SureCN7390271 family 2 1
Type-1 angiotensin II receptor ligand SureCN9402249 family 4 7
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 0
Type-1B angiotensin II receptor ligand SureCN9309010 family 5 1
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 3 3
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 1 0
Alpha-1A adrenergic receptor and Alpha-2A adrenergic receptor ... 3 0
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
Type-1 angiotensin II receptor ligand AGN-PC-04X8EF family 1 1
Gonadotropin-releasing hormone receptor ligand 4-[[4-[2-(4-ter... 3 3
Type-1B angiotensin II receptor and Type-2 angiotensin II rece... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00418361 CHEMBL2337677 Bioactive [4-butyl-1,3-bis[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-1-ium-2-yl]methanol;bromide
CFAMM00418360 CHEMBL345404 Bioactive SureCN9448582
CFAMM00418359 CHEMBL2337686 Bioactive 5-[2-[4-[[4-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-1-ium-1-yl]methyl]phenyl]phenyl]-2H-tetrazole;bromide
CFAMM00418357 CHEMBL75935 Bioactive AGN-PC-0034NF

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27298 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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