CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12813
Family Name cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cGMP-inhibited 3',5'-cyclic phosphodiesterase A inhibitor 6-[7-methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-4-yl]-5-methyl-2-[4-[4-(4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl)phenoxy]butyl]-4,5-dihydropyridazin-3-one family
No. of Seeds 18 No. of Other Members 10
Family Centroid CFAMM00418380 Functional Category Bioactive
Superfamily Coagulation factor X Inhibitor Apixaban Superfamily
Class Class 999

Cousin Family NamesSeedsMembers
Peroxisome proliferator-activated receptor gamma Ligand Piogli... 2 29
Glycogen synthase kinase-3 beta inhibitor AGN-PC-07ZA5M family 4 14
Cannabinoid receptor 1 and 5-hydroxytryptamine receptor 1A lig... 2 12
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Cannabinoid receptor 1 ligand NIDA-41020 family 7 5
Histamine H3 receptor ligand 3-[4-[3-[(2R)-2-methylpyrrolidin-... 1 5
Coagulation factor X inhibitor SureCN6785555 family 7 0
Coagulation factor X inhibitor SureCN5644036 family 30 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00418400 CHEMBL2337965 Bioactive 2-[4-[4-(4,4-dimethyl-5-oxo-1H-pyrazol-3-yl)-2-fluorophenoxy]butyl]-6-[7-methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-4-yl]-5-methyl-4,5-dihydropyridazin-3-one
CFAMM00418387 CHEMBL2337956 Bioactive 6-[7-methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-4-yl]-5-methyl-2-[2-[4-(4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl)phenoxy]ethyl]-4,5-dihydropyridazin-3-one
CFAMM00418380 CHEMBL2337958 Bioactive 6-[7-methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-4-yl]-5-methyl-2-[4-[4-(4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl)phenoxy]butyl]-4,5-dihydropyridazin-3-one
CFAMM00418386 CHEMBL2337957 Bioactive 6-[7-methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-4-yl]-5-methyl-2-[3-[4-(4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl)phenoxy]propyl]-4,5-dihydropyridazin-3-one
CFAMM00418399 CHEMBL2337964 Bioactive 2-[4-[3-(4,4-dimethyl-5-oxo-1H-pyrazol-3-yl)phenoxy]butyl]-6-[7-methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-4-yl]-5-methyl-4,5-dihydropyridazin-3-one
CFAMM00418379 CHEMBL2337959 Bioactive 3-[4-[4-[3-[7-methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-4-yl]-4-methyl-6-oxo-4,5-dihydropyridazin-1-yl]butoxy]phenyl]-4-methyl-1H-pyridazin-6-one
CFAMM00418385 CHEMBL2337954 Bioactive 6-(2-ethyl-7-methoxypyrazolo[1,5-a]pyridin-4-yl)-5-methyl-2-[3-[4-(4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl)phenoxy]propyl]-4,5-dihydropyridazin-3-one
CFAMM00418398 CHEMBL2337963 Bioactive 6-[7-methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-4-yl]-5-methyl-2-[4-[3-(4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl)phenoxy]butyl]-4,5-dihydropyridazin-3-one
CFAMM00418404 CHEMBL2337969 Bioactive 6-(2-ethyl-7-methoxypyrazolo[1,5-a]pyridin-4-yl)-2-[4-[4-(4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl)phenoxy]butyl]-4,5-dihydropyridazin-3-one
CFAMM00418397 CHEMBL2337962 Bioactive 2-[4-[4-(4,4-dimethyl-5-oxo-1H-pyrazol-3-yl)phenoxy]butyl]-6-[7-methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-4-yl]-5-methyl-4,5-dihydropyridazin-3-one
CFAMM00418390 CHEMBL2337976 Bioactive 6-[7-methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-4-yl]-5-methyl-2-[5-[4-(4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl)phenoxy]pentyl]-4,5-dihydropyridazin-3-one
CFAMM00418403 CHEMBL2337968 Bioactive 2-[4-[2,3-difluoro-4-(6-oxo-4,5-dihydro-1H-pyridazin-3-yl)phenoxy]butyl]-6-[7-methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-4-yl]-5-methyl-4,5-dihydropyridazin-3-one
CFAMM00418383 CHEMBL2337953 Bioactive 6-(2-ethyl-7-methoxypyrazolo[1,5-a]pyridin-4-yl)-5-methyl-2-[4-[4-(4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl)phenoxy]butyl]-4,5-dihydropyridazin-3-one
CFAMM00418402 CHEMBL2337967 Bioactive 2-[4-[4-(4,4-dimethyl-5-oxo-1H-pyrazol-3-yl)-2,3-difluorophenoxy]butyl]-6-[7-methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-4-yl]-5-methyl-4,5-dihydropyridazin-3-one
CFAMM00418382 CHEMBL2337970 Bioactive 6-(2-ethyl-7-methoxypyrazolo[1,5-a]pyridin-4-yl)-2-[4-[4-(4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl)phenoxy]butyl]pyridazin-3-one
CFAMM00418395 CHEMBL2337960 Bioactive 6-[7-methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-4-yl]-5-methyl-2-[4-[4-(6-oxo-4,5-dihydro-1H-pyridazin-3-yl)phenoxy]butyl]-4,5-dihydropyridazin-3-one
CFAMM00418401 CHEMBL2337966 Bioactive 2-[4-[4-(4,4-dimethyl-5-oxo-1H-pyrazol-3-yl)-3-fluorophenoxy]butyl]-6-[7-methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-4-yl]-5-methyl-4,5-dihydropyridazin-3-one
CFAMM00418381 CHEMBL2337971 Bioactive 3-[4-[4-[3-(2-ethyl-7-methoxypyrazolo[1,5-a]pyridin-4-yl)-4,4-dimethyl-5-oxopyrazol-1-yl]butoxy]phenyl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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