CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12821
Family Name Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 5-(5-hydroxy-2-adamantyl)-8,8-dimethyl-1-phenyl-6,7-dihydropyrazolo[4,3-c]azepin-4-one family
No. of Seeds 10 No. of Other Members 6
Family Centroid CFAMM00418437 Functional Category Bioactive
Superfamily Corticosteroid 11-beta-dehydrogenase isozyme 1 Binder Superfamily 19
Class Class 4937

Cousin Family NamesSeedsMembers
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 1 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 5-(5-... 1 0


External ID

Functional Category

Molecule Name

CFAMM00418437 CHEMBL2338264 Bioactive 5-(5-hydroxy-2-adamantyl)-8,8-dimethyl-1-phenyl-6,7-dihydropyrazolo[4,3-c]azepin-4-one
CFAMM00418443 CHEMBL2338246 Bioactive 5-(5-hydroxy-2-adamantyl)-8,8-dimethyl-1-(3-methylphenyl)-6,7-dihydropyrazolo[4,3-c]azepin-4-one
CFAMM00418436 CHEMBL2338266 Bioactive 5-(5-hydroxy-2-adamantyl)-7,7-dimethyl-1-phenyl-6,8-dihydropyrazolo[4,3-c]azepin-4-one
CFAMM00418449 CHEMBL2338250 Bioactive 1-(3-fluorophenyl)-5-(5-hydroxy-2-adamantyl)-8,8-dimethyl-6,7-dihydropyrazolo[4,3-c]azepin-4-one
CFAMM00418435 CHEMBL2338254 Bioactive 5-(5-hydroxy-2-adamantyl)-8,8-dimethyl-1-[3-(trifluoromethyl)phenyl]-6,7-dihydropyrazolo[4,3-c]azepin-4-one
CFAMM00418448 CHEMBL2338251 Bioactive 1-(4-fluorophenyl)-5-(5-hydroxy-2-adamantyl)-8,8-dimethyl-6,7-dihydropyrazolo[4,3-c]azepin-4-one
CFAMM00418447 CHEMBL2338252 Bioactive 1-(3-chlorophenyl)-5-(5-hydroxy-2-adamantyl)-8,8-dimethyl-6,7-dihydropyrazolo[4,3-c]azepin-4-one
CFAMM00418440 CHEMBL2338245 Bioactive 5-(5-hydroxy-2-adamantyl)-8,8-dimethyl-1-(2-methylphenyl)-6,7-dihydropyrazolo[4,3-c]azepin-4-one
CFAMM00418446 CHEMBL2338253 Bioactive 1-(4-chlorophenyl)-5-(5-hydroxy-2-adamantyl)-8,8-dimethyl-6,7-dihydropyrazolo[4,3-c]azepin-4-one
CFAMM00418445 CHEMBL2338247 Bioactive 5-(5-hydroxy-2-adamantyl)-8,8-dimethyl-1-(4-methylphenyl)-6,7-dihydropyrazolo[4,3-c]azepin-4-one

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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