CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1286
Family Name Sterol O-acyltransferase 1 inhibitor 1-(2,4-difluorophenyl)-3-[5-[(4,5-diphenyl-1H-imidazol-2-yl)sulfanyl]pentyl]-1-heptylurea family
No. of Seeds 8 No. of Other Members 90
Family Centroid CFAMM00321418 Functional Category Bioactive
Superfamily Orexin receptor type 2 and Orexin receptor type 1 Binder Superfamily
Class Class 877

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Mizolastine Family 14 603
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
BIBT986 family 7 96
Tryptase Inhibitor Babim Family 12 90
Histamine H3 receptor and Histamine H4 receptor Ligand Clobenp... 31 38
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 22
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-(2-(4-... 25 10
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 3
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 6 3
Mitogen-activated protein kinase 14 inhibitor 6-[5-(2,4-difluo... 9 3
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-[4-(1H-benzimidazo... 3 5
Neuropeptide Y receptor type 5 ligand 2-(3-phenylpiperidin-1-y... 6 2
Mitogen-activated protein kinase 14 inhibitor 6-[2-(2,6-difluo... 3 0
Carbonic anhydrase 7 and Carbonic anhydrase 13 inhibitor 4-[(4... 1 5
Orexin receptor type 2 and Orexin receptor type 1 ligand (2S)-... 5 0
Orexin receptor type 2 and Orexin receptor type 1 ligand (2S)-... 2 2
Nociceptin receptor ligand 6-fluoro-2-pentan-3-ylsulfanyl-5-pi... 1 4
Nociceptin receptor ligand 2-[(2,3-dichlorophenyl)methylsulfan... 1 1
Mitogen-activated protein kinase 14 inhibitor SureCN828349 family 1 0
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[2-(1H-benzimidaz... 3 14
Histamine H3 receptor ligand 5-(3-bromophenyl)-2-[2-(1H-imidaz... 2 2
Sterol O-acyltransferase 1 inhibitor SureCN9766896 family 4 23
Sterol O-acyltransferase 1 inhibitor (4R,6R)-6-[[4,5-bis(3-met... 2 7
Sterol O-acyltransferase 1 inhibitor SureCN9370585 family 1 0
Acyl-CoA:cholesterol acyltransferase and Sterol O-acyltransfer... 3 2
Sterol O-acyltransferase 1 inhibitor AGN-PC-075SUK family 1 0
Sterol O-acyltransferase 1 inhibitor AGN-PC-025JYX family 1 1
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8920007 f... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00321453 CHEMBL333013 Bioactive SureCN9370500
CFAMM00321385 CHEMBL115514 Bioactive SureCN9370595
CFAMM00321431 CHEMBL119484 Bioactive AGN-PC-00FJRP
CFAMM00321378 CHEMBL274185 Bioactive Lecimibide
CFAMM00321472 CHEMBL119295 Bioactive SureCN9370479
CFAMM00321470 CHEMBL431940 Bioactive SureCN9351854
CFAMM00321388 CHEMBL119678 Bioactive SureCN9370240
CFAMM00321418 CHEMBL125701 Bioactive 1-(2,4-difluorophenyl)-3-[5-[(4,5-diphenyl-1H-imidazol-2-yl)sulfanyl]pentyl]-1-heptylurea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27520 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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