CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12865
Family Name Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,4-dimethyl-N-(6-methylpyridin-2-yl)pyrazole-3-carboxamide family
No. of Seeds 7 No. of Other Members 1
Family Centroid CFAMM00418642 Functional Category Bioactive
Superfamily Metabotropic glutamate receptor 5 and Menin Binder Superfamily
Class Class 1286

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Prothrombin Inhibitor Dabigatran Family 7 182
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 5 129
Tyrosine-protein kinase Lck and Aurora kinase B Inhibitor VX-6... 28 56
Mitogen-activated protein kinase 12 Inhibitor VX-702 Family 3 49
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
PHA848125 family 13 138
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Smoothened homolog Inhibitor LY2940680 Family 3 18
JAK Inhibitor Momelotinib Family 33 83
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Aurora kinase B and Aurora kinase C Inhibitor PHA-680632 Family 5 72
Metabotropic glutamate receptor 5 Ligand N-(1,4-diphenyl-1h-py... 3 35
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Metabotropic glutamate receptor 5 Ligand N-(1,3-diphenyl-1h-py... 6 37
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Prothrombin inhibitor 2-[(2S)-1-[(2R)-2-amino-3-phenylpropanoy... 3 16
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 4
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 1 8
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZYJE fa... 15 5
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 3
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Mitogen-activated protein kinase 14 inhibitor SureCN3632376 fa... 10 5
Mitogen-activated protein kinase 13 inhibitor N-cyclopropyl-3-... 16 40
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 18
Adenosine receptor A3 ligand AGN-PC-07N4XX family 6 10
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 5 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07ZE3... 6 1
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07RDWA fa... 1 4
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor 1-methyl-8-(... 1 1
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
RAC-alpha serine/threonine-protein kinase inhibitor SureCN4728... 11 6
Poly [ADP-ribose] polymerase 1 inhibitor 2-[2-[4-(1H-indazol-3... 1 0
Smoothened homolog inhibitor SureCN1091571 family 2 2
Substance-P receptor ligand (3R,4S)-N-[[3,5-bis(trifluoromethy... 3 7
Transient receptor potential cation channel subfamily V member... 1 4
5-hydroxytryptamine receptor 2A ligand AGN-PC-04RTMN family 7 5
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Mitogen-activated protein kinase 14 inhibitor 3mvm family 6 1
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
TGF-beta receptor type-1 ligand 6-[4-ethyl-2-(6-methylpyridin-... 9 11
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 10
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M8RE fa... 6 1
Mitogen-activated protein kinase kinase kinase kinase 5 and Du... 1 18
Adenosine receptor A1 ligand AGN-PC-07PMLW family 6 4
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M4U... 4 5
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M45... 8 1
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 9
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 19
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M6OU fa... 8 7
Mitogen-activated protein kinase 14 inhibitor AGN-PC-069K8I fa... 12 3
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 6
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Coagulation factor X and Trypsin-1 inhibitor SureCN3836037 family 5 4
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 21
Prothrombin and Survival motor neuron protein inhibitor CHEMBL... 2 14
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 3
Survival motor neuron protein inhibitor CHEMBL1583999 family 1 3
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 8 13
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
Aurora kinase A inhibitor AGN-PC-00EHLC family 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 34 4
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07CBUP family 2 3
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 1 4
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 15 7
Cannabinoid receptor 1 ligand N-[1-[[(1R)-1-[4-(3-chloroindazo... 10 0
Mitogen-activated protein kinase 14 inhibitor N-ethyl-5-methyl... 17 3
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 13 3
Smoothened homolog inhibitor (8aS)-N-[2-(3-chlorophenyl)pyrazo... 2 0
Beta-secretase 1 and Beta-secretase 2 inhibitor (5S)-2-amino-5... 3 39
Coagulation factor X inhibitor AGN-PC-0749BY family 5 9
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
TGF-beta receptor type-1 ligand 3-[[3-(6-methylpyridin-2-yl)-4... 1 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 0
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 11 0
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 6 1
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 3 6
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... 4 0
Hepatocyte growth factor receptor ligand 5-[(6-phenyl-[1,2,4]t... 6 2
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
Corticotropin-releasing factor receptor 1 ligand 2-[6-(dimethy... 1 4
Prothrombin inhibitor 2-[3-cyano-6-(2,2-difluoro-2-pyridin-2-y... 3 0
Mitogen-activated protein kinase 14 inhibitor ethyl N-[4-[5-(m... 5 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 10 0
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Cell division cycle 7-related protein kinase and Casein kinase... 2 0
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Aurora kinase B and Aurora kinase A inhibitor (2S)-1-[4-[[1-[(... 12 4
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 6 0
Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]... 3 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
DNA gyrase subunit B inhibitor 5-[2-(ethylcarbamoyl)-4-[3-(tri... 2 4
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 16 5
Coagulation factor X inhibitor AGN-PC-02WFR7 family 7 13
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Renin inhibitor AGN-PC-073MLF family 7 6
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 12 0
Tyrosine-protein kinase SYK and Potassium voltage-gated channe... 1 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 4 2
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 3 0
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
P2X purinoceptor 7 inhibitor SureCN109149 family 8 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Cathepsin K and Cathepsin S inhibitor ketone analog, 3m family 1 2
G-protein coupled bile acid receptor 1 ligand 2-(ethylamino)-6... 5 4
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 3
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial ... 1 3
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... 5 1
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Metabotropic glutamate receptor 5 ligand 5-(4-chlorophenyl)-1,... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 1
Mast/stem cell growth factor receptor Kit and Proto-oncogene t... 3 5
Tyrosine-protein kinase JAK2 inhibitor N-(3-methylphenyl)-5-(3... 2 4
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor AGN-... 1 1
B1 bradykinin receptor ligand SureCN6045889 family 4 9
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Casein kinase II subunit alpha inhibitor CHEMBL401945 family 12 1
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 1
Cannabinoid receptor 1 ligand AGN-PC-07R6QU family 4 2
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 6 6
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 7
Alpha-1B adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 2 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 2
Type-1 angiotensin II receptor ligand 2-[(2-ethyl-5,7-dimethyl... 5 3
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 13
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 5 1
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 1 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand (2... 1 0
Rho-associated protein kinase 1 and Ribosomal protein S6 kinas... 4 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 11 1
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Aurora kinase A and Aurora kinase B inhibitor N-[(3E)-3-[5-(mo... 3 2
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Collagenase 3 inhibitor MMP-13 Inhibitor family 1 1
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-04VNKY family 1 4
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (3... 1 1
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 16 3
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Cannabinoid receptor 1 ligand AGN-PC-07R6O8 family 5 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07B2Q... 6 0
Cannabinoid receptor 1 ligand AGN-PC-07RA6C family 21 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07RBL... 5 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R6UP family 2 0
Poly [ADP-ribose] polymerase 1 inhibitor SureCN6479420 family 1 0
Glucagon receptor ligand AGN-PC-0DAH9I family 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-00CRQ3 fa... 1 2
Vascular endothelial growth factor receptor 2 and Vascular end... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00418638 CHEMBL2349538 Bioactive 5-(2,4-difluorophenyl)-1,4-dimethyl-N-(6-methylpyridin-2-yl)pyrazole-3-carboxamide
CFAMM00418636 CHEMBL2346721 Bioactive N-(2-chloropyrimidin-4-yl)-5-(4-fluorophenyl)-1,4-dimethylpyrazole-3-carboxamide
CFAMM00418642 CHEMBL2349534 Bioactive 5-(4-fluorophenyl)-1,4-dimethyl-N-(6-methylpyridin-2-yl)pyrazole-3-carboxamide
CFAMM00418635 CHEMBL2349541 Bioactive 1,4-dimethyl-5-(4-methylphenyl)-N-(6-methylpyridin-2-yl)pyrazole-3-carboxamide
CFAMM00418641 CHEMBL2349537 Bioactive 5-(3,4-difluorophenyl)-1,4-dimethyl-N-(6-methylpyridin-2-yl)pyrazole-3-carboxamide
CFAMM00418640 CHEMBL2349533 Bioactive 1,4-dimethyl-N-(6-methylpyridin-2-yl)-5-phenylpyrazole-3-carboxamide
CFAMM00418639 CHEMBL2349539 Bioactive 5-(3,5-difluorophenyl)-1,4-dimethyl-N-(6-methylpyridin-2-yl)pyrazole-3-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27273 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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