CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1287
Family Name Platelet-activating factor receptor ligand SureCN9523843 family
No. of Seeds 4 No. of Other Members 4
Family Centroid CFAMM00321488 Functional Category Bioactive
Superfamily Platelet-activating factor receptor and Glucosylceramidase Binder Superfamily
Class Class 2257

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Prothrombin Inhibitor Dabigatran Family 7 182
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Translocator protein Inhibitor Emapunil Family 7 89
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
CC-486 family 7 103
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Kappa-type opioid receptor Ligand Brl 52974 Family 2 27
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Histamine H3 receptor Ligand SCH79687 Family 11 29
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 1 4
Poly [ADP-ribose] polymerase 1 inhibitor 2-(3-chlorophenyl)-1H... 4 38
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Platelet-activating factor receptor ligand 8-bromo-2-[4-(2-met... 2 2
Platelet-activating factor receptor ligand 5-methyl-2-[4-(2-me... 1 2
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Lysosomal Pro-X carboxypeptidase inhibitor 2-amino-N-[(2S)-1-[... 11 16
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 9
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
5-hydroxytryptamine receptor 4 ligand 6-chloro-N-[[1-(2-methyl... 10 19
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 2
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 8 13
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 14
Prothrombin inhibitor AGN-PC-09QLAK family 10 2
Lysosomal Pro-X carboxypeptidase inhibitor N-[(1S)-1-(5,6-dich... 3 21
Lysosomal Pro-X carboxypeptidase inhibitor 1-[(2S)-2-(5,6-dich... 2 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 14
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 1 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 8
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Coagulation factor X inhibitor SureCN8289965 family 4 5
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X3N ... 1 7
Heat shock protein HSP 90-beta inhibitor 1-(2-amino-4-methylqu... 1 2
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 0
Substance-P receptor ligand SureCN7659714 family 2 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
P2X purinoceptor 7 inhibitor SureCN9931311 family 2 0
P2X purinoceptor 7 inhibitor SureCN113576 family 2 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 5
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Transient receptor potential cation channel subfamily V member... 1 1
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Metabotropic glutamate receptor 2 ligand 8-(2,5-difluorophenyl... 6 2
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Diacylglycerol O-acyltransferase 1 inhibitor 2-[4-[4-[5-(6-chl... 2 0
Substance-K receptor ligand SureCN9035669 family 10 5
Thromboxane-A synthase inhibitor 6-chloro-3-(4-imidazol-1-ylbu... 12 21
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 2 0
Coagulation factor X inhibitor SureCN1652469 family 2 1
Coagulation factor X inhibitor AGN-PC-078Y0T family 11 0
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Translocator protein inhibitor AGN-PC-04X3HY family 10 1
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Sonic hedgehog protein and Cytochrome P450 2C9 inhibitor AGN-P... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R96X family 7 1
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 inhibi... 3 7


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00321483 CHEMBL115529 Bioactive 7,8-dichloro-4-[4-(2-methylimidazo[4,5-c]pyridin-1-yl)phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one
CFAMM00321488 CHEMBL324709 Bioactive SureCN9523843
CFAMM00321487 CHEMBL116198 Bioactive SureCN9695814
CFAMM00321485 CHEMBL334275 Bioactive SureCN9524948

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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