CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12871
Family Name Beta-secretase 1 inhibitor N-[3-[(4R,5R,6S)-2-amino-5-fluoro-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide family
No. of Seeds 4 No. of Other Members 11
Family Centroid CFAMM00418674 Functional Category Bioactive
Superfamily Beta-secretase 1 and Beta-secretase 2 Binder Superfamily 10
Class Class 3069

Cousin Family NamesSeedsMembers
Substance-P receptor Ligand TAK-637 Family 18 63
secretase Inhibitor LY2886721 Family 1 2
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Transient receptor potential cation channel subfamily V member... 6 23
Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 2 11
Beta-secretase 2 and Beta-secretase 1 inhibitor N-[3-[(1S,7S)-... 7 4
Beta-secretase 1 and Beta-secretase 2 inhibitor N-[3-[(4S)-2-a... 6 4
Beta-secretase 1 and Beta-secretase 2 inhibitor SureCN14726714... 4 1
Beta-secretase 2 and Beta-secretase 1 inhibitor N-[3-[(4R)-2-a... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00418662 CHEMBL2347204 Bioactive N-[3-[(4R,5R)-2-amino-5-fluoro-4-methyl-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
CFAMM00418675 CHEMBL2347208 Bioactive N-[3-[(4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
CFAMM00418668 CHEMBL2347206 Bioactive N-[3-[(4S)-2-amino-4-(difluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
CFAMM00418674 CHEMBL2347188 Bioactive N-[3-[(4R,5R,6S)-2-amino-5-fluoro-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

44855 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543