CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12876
Family Name Orexin receptor type 2 and Orexin receptor type 1 ligand (2R)-2-[(8S)-1-chloro-8-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-3-ethyl-6,8-dihydro-5H-imidazo[1,5-a]pyrazin-7-yl]-N-methyl-2-phenylacetamide family
No. of Seeds 12 No. of Other Members 16
Family Centroid CFAMM00418716 Functional Category Bioactive
Superfamily Orexin receptor type 2 and Orexin receptor type 1 Binder Superfamily 6
Class Class 86

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
C-C chemokine receptor type 5 Ligand Maraviroc Family 29 81
Histamine H1 receptor Ligand Mizolastine Family 14 603
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Dipeptidyl peptidase 4 Inhibitor SSR-162369 Family 8 27
BIBT986 family 7 96
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
SB989 family 17 91
Kappa-type opioid receptor Ligand Brl 52974 Family 2 27
Histamine H3 receptor Ligand SCH79687 Family 11 29
Farnesyltransferase beta subunit, putative and Protein farnesy... 20 81
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 45
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SCH-577... 9 29
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
Acetylcholinesterase inhibitor SureCN251059 family 2 16
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Histone deacetylase 1 and Histone deacetylase 8 inhibitor (E)-... 3 0
C-C chemokine receptor type 5 ligand [3-[2-[(3aS,6aR)-5-(4,6-d... 3 40
Dipeptidyl peptidase 4 inhibitor AGN-PC-046QKE family 3 5
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 28 9
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Substance-P receptor ligand (3R,4S)-N-[[3,5-bis(trifluoromethy... 3 7
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 3
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Adenosine receptor A3 and Adenosine receptor A1 ligand (8R)-8-... 4 0
RAC-alpha serine/threonine-protein kinase inhibitor 2-[(3,4-di... 3 1
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 9 3
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Bile acid receptor and Potassium voltage-gated channel subfami... 2 1
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
C-C chemokine receptor type 5 ligand methyl N-cyano-4-[2-[(1R,... 8 8
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 10 14
Histamine H3 receptor ligand SureCN2878688 family 8 1
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Cdc2-related kinase inhibitor N-[6-(3,5-dimethylphenyl)-1-meth... 1 0
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 2 1
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-(6-pyrrolid... 3 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
G-protein coupled bile acid receptor 1 ligand 2-(ethylamino)-6... 5 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 7 2
Prothrombin inhibitor 2-[4-methyl-5-[[[2-[6-methyl-2-oxo-3-(2-... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 1
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Orexin receptor type 2 and Orexin receptor type 1 ligand (2R)-... 2 0
B1 bradykinin receptor ligand AGN-PC-077LWO family 2 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (3... 1 1
Dipeptidyl peptidase 4 inhibitor AGN-PC-046QKJ family 1 0
P2X purinoceptor 7 inhibitor N-[(3-chloro-2-methylphenyl)methy... 7 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00418722 CHEMBL2396839 Bioactive (2R)-2-[(8S)-1-chloro-3-cyclopropyl-8-[2-[3-(trifluoromethyl)phenyl]ethyl]-6,8-dihydro-5H-imidazo[1,5-a]pyrazin-7-yl]-N-methyl-2-phenylacetamide
CFAMM00418708 CHEMBL2396861 Bioactive (2R)-2-[(8S)-1-chloro-3-ethyl-8-[2-[3-(trifluoromethyl)phenyl]ethyl]-6,8-dihydro-5H-imidazo[1,5-a]pyrazin-7-yl]-N-methyl-2-phenylacetamide
CFAMM00418707 CHEMBL2396867 Bioactive (2R)-2-[(8S)-1-chloro-3-ethyl-8-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-6,8-dihydro-5H-imidazo[1,5-a]pyrazin-7-yl]-N-methyl-2-phenylacetamide
CFAMM00418700 CHEMBL250285 Bioactive (3R)-3-amino-1-[4-[(4-fluorophenyl)methyl]-1-methyl-2-(trifluoromethyl)-6,7-dihydro-4H-imidazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
CFAMM00418719 CHEMBL2347482 Bioactive (2R)-2-[(8S)-1-chloro-3-ethyl-8-[2-[4-(trifluoromethyl)phenyl]ethyl]-6,8-dihydro-5H-imidazo[1,5-a]pyrazin-7-yl]-N-methyl-2-phenylacetamide
CFAMM00418699 CHEMBL250284 Bioactive (3R)-3-amino-1-[4-benzyl-1-methyl-2-(trifluoromethyl)-6,7-dihydro-4H-imidazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
CFAMM00418711 CHEMBL2396840 Bioactive (2R)-2-[(8S)-1-chloro-3-cyclopropyl-8-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-6,8-dihydro-5H-imidazo[1,5-a]pyrazin-7-yl]-N-methyl-2-phenylacetamide
CFAMM00418723 CHEMBL2396838 Bioactive (2R)-2-[(8S)-1-chloro-3-ethyl-8-[2-[2-fluoro-3-(trifluoromethyl)phenyl]ethyl]-6,8-dihydro-5H-imidazo[1,5-a]pyrazin-7-yl]-N-methyl-2-phenylacetamide
CFAMM00418703 CHEMBL2347607 Bioactive (2R)-2-[(8S)-1-chloro-3-cyclopropyl-8-[2-[4-(trifluoromethyl)phenyl]ethyl]-6,8-dihydro-5H-imidazo[1,5-a]pyrazin-7-yl]-N-methyl-2-phenylacetamide
CFAMM00418716 CHEMBL2396835 Bioactive (2R)-2-[(8S)-1-chloro-8-[2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethyl]-3-ethyl-6,8-dihydro-5H-imidazo[1,5-a]pyrazin-7-yl]-N-methyl-2-phenylacetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27257 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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