CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12895
Family Name Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-chloro-1-methylindazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00418800 Functional Category Bioactive
Superfamily Tyrosine-protein kinase JAK2 and Cannabinoid receptor 2 Binder Superfamily
Class Class 3858

Cousin Family NamesSeedsMembers
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Histamine H3 receptor Ligand SCH79687 Family 11 29
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Adenosine receptor A2b Ligand CVT-7124 Family 14 64
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
Orexin receptor type 1 and Orexin receptor type 2 ligand AGN-P... 2 24
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07RDWA fa... 1 4
Adenosine receptor A1 ligand SureCN10614388 family 5 1
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Dipeptidyl peptidase 8 and Dipeptidyl peptidase 4 inhibitor Su... 5 13
Aurora kinase A and Aurora kinase B inhibitor 3uol family 6 5
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 10
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 9
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Tyrosine-protein kinase JAK2 inhibitor N-[2-(3-chlorophenyl)-5... 2 11
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 8 13
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 5-(2-... 6 83
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Cannabinoid receptor 1 ligand 5-(4-chlorophenyl)-1-(2,4-dichlo... 2 19
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 11
Coagulation factor X inhibitor AGN-PC-0749BY family 5 9
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL1... 7 4
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 6 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 5-(2-... 12 1
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Cell division cycle 7-related protein kinase and Dual specific... 3 1
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Aurora kinase B and Aurora kinase A inhibitor (2S)-1-[4-[[1-[(... 12 4
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 3 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
DNA gyrase subunit B inhibitor 5-[2-(ethylcarbamoyl)-4-[3-(tri... 2 4
Casein kinase II subunit alpha and Homeodomain-interacting pro... 5 0
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 12 0
Tyrosine-protein kinase JAK2 and Cytochrome P450 3A4 inhibitor... 1 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
P2X purinoceptor 7 inhibitor SureCN109149 family 8 1
P2X purinoceptor 7 inhibitor SureCN9931311 family 2 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Adenosine receptor A1 and Adenosine receptor A3 ligand N-benzy... 4 2
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-[5-(diflu... 7 0
Tyrosine-protein kinase SYK and Cytochrome P450 2D6 inhibitor ... 3 0
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... 5 1
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 0
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 12 3
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 3 0
Histone deacetylase 1 and Proto-oncogene tyrosine-protein kina... 4 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Adenosine receptor A2b ligand N-(4-chlorophenyl)-2-[(5Z)-5-(2,... 1 2
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Epidermal growth factor receptor and Receptor tyrosine-protein... 5 8
Tripeptidyl-peptidase 2 inhibitor (2S)-2-amino-1-[(2S)-5-chlor... 1 0
Serine/threonine-protein kinase B-raf inhibitor 1-[2-[[4-[2-cy... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Vasopressin V2 receptor and Vasopressin V1a receptor ligand (2... 1 0
Aurora kinase A and Aurora kinase B inhibitor N-[(3E)-3-[5-(mo... 3 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Cannabinoid receptor 1 ligand AGN-PC-07R6O8 family 5 2
Cannabinoid receptor 1 ligand AGN-PC-07RA6C family 21 2
Cannabinoid receptor 1 ligand AGN-PC-07RA3R family 15 0
Glutamate racemase inhibitor 5-[5-but-2-ynyl-2-[(6-chloroquino... 9 8
Adenosine receptor A2b ligand N-[(3Z)-3-(2,6-dioxo-1,3-dipropy... 1 0
Glutamate racemase inhibitor AGN-PC-077KKZ family 6 0
Glutamate racemase inhibitor AGN-PC-077KMZ family 6 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00418800 CHEMBL2348853 Bioactive N-tert-butyl-2-(6-chloro-1-methylindazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
CFAMM00418801 CHEMBL2348856 Bioactive 2-(6-chloro-1-methylindazol-3-yl)-N-(1-hydroxy-2-methylpropan-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27510 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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