CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12904
Family Name Metabotropic glutamate receptor 5 ligand 5-(4-chlorophenyl)-1,4-dimethyl-N-(6-methylpyridin-2-yl)pyrazole-3-carboxamide family
No. of Seeds 3 No. of Other Members 1
Family Centroid CFAMM00418886 Functional Category Bioactive
Superfamily Metabotropic glutamate receptor 5 and Menin Binder Superfamily
Class Class 1286

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Cannabinoid receptor 1 Ligand Rimonabant Family 20 260
Cannabinoid receptor 1 Ligand TM38837 Family 20 15
PHA848125 family 13 138
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Metabotropic glutamate receptor 5 Ligand N-(1,3-diphenyl-1h-py... 6 37
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZYJE fa... 15 5
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 3
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07ZE3... 6 1
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 3 59
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M8RE fa... 6 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 8 16
Mitogen-activated protein kinase 14 inhibitor AGN-PC-00CSYM fa... 2 15
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M6OU fa... 8 7
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Coagulation factor X and Trypsin-1 inhibitor SureCN3836037 family 5 4
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 21
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 5-(2-... 6 83
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 34 4
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Cannabinoid receptor 1 ligand N-[1-[[(1R)-1-[4-(3-chloroindazo... 10 0
Cannabinoid receptor 1 ligand 5-(4-chlorophenyl)-1-(2,4-dichlo... 2 19
Cannabinoid receptor 1 ligand 5-(4-chlorophenyl)-1-(2,4-dichlo... 8 0
Cannabinoid receptor 1 ligand 5-(4-chlorophenyl)-1-(2,4-dichlo... 1 0
Beta-secretase 1 and Beta-secretase 2 inhibitor (5S)-2-amino-5... 3 39
G1/S-specific cyclin-E2 and G1/S-specific cyclin-E1 inhibitor ... 5 10
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 3 6
Corticotropin-releasing factor receptor 1 ligand 2-[6-(dimethy... 1 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
Cannabinoid receptor 1 ligand SureCN4819820 family 11 5
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 16 5
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0YSZ... 10 0
Non-receptor tyrosine-protein kinase TYK2 ligand SureCN1298914... 3 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
B1 bradykinin receptor ligand SureCN6045889 family 4 9
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Cannabinoid receptor 1 ligand AGN-PC-07R6QU family 4 2
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Cannabinoid receptor 1 ligand AGN-PC-07NHJ5 family 9 1
Vasopressin V2 receptor and Vasopressin V1a receptor ligand (2... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-04VNKY family 1 4
Cannabinoid receptor 1 ligand AGN-PC-07R5TU family 11 0
Cannabinoid receptor 1 ligand AGN-PC-07R6O8 family 5 2
Cannabinoid receptor 1 ligand AGN-PC-07RA6C family 21 2
Cannabinoid receptor 1 ligand AGN-PC-07RA3R family 15 0
Cannabinoid receptor 1 ligand AGN-PC-07R6QS family 5 0
Cannabinoid receptor 1 ligand AGN-PC-07R9T4 family 27 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00418886 CHEMBL2349535 Bioactive 5-(4-chlorophenyl)-1,4-dimethyl-N-(6-methylpyridin-2-yl)pyrazole-3-carboxamide
CFAMM00418885 CHEMBL2349536 Bioactive 5-(3-chlorophenyl)-1,4-dimethyl-N-(6-methylpyridin-2-yl)pyrazole-3-carboxamide
CFAMM00418884 CHEMBL2349540 Bioactive 5-(3,4-dichlorophenyl)-1,4-dimethyl-N-(6-methylpyridin-2-yl)pyrazole-3-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24631 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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