CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12920
Family Name Gonadotropin-releasing hormone receptor ligand 6-[(4-chloro-2-methylphenyl)methyl]-1-[(2,6-difluorophenyl)methyl]-3-[2-[methyl(2-pyridin-2-ylethyl)amino]ethyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-2,4-dione family
No. of Seeds 3 No. of Other Members 3
Family Centroid CFAMM00419036 Functional Category Bioactive
Superfamily Gonadotropin-releasing hormone receptor Binder Superfamily 3
Class Class 1209

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Substance-P receptor Ligand TAK-637 Family 18 63
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Alpha-1A adrenergic receptor Ligand L-771688 Family 8 14
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 4
Gonadotropin-releasing hormone receptor ligand AGN-PC-075KV1 f... 4 1
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Gonadotropin-releasing hormone receptor ligand 1-[(2,6-difluor... 2 17
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 7 7
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
Glucocorticoid receptor ligand 5-[(6-methylpyridin-2-yl)methyl... 3 0


External ID

Functional Category

Molecule Name

CFAMM00419033 CHEMBL236152 Bioactive 6-[(4-chlorophenyl)methyl]-1-[(2,6-difluorophenyl)methyl]-3-[[(2R)-1-(2-pyridin-2-ylethyl)pyrrolidin-2-yl]methyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-2,4-dione
CFAMM00419038 CHEMBL235270 Bioactive 1-[(2,6-difluorophenyl)methyl]-6-[(2,4-dimethylphenyl)methyl]-3-[2-[methyl(2-pyridin-2-ylethyl)amino]ethyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-2,4-dione
CFAMM00419036 CHEMBL392605 Bioactive 6-[(4-chloro-2-methylphenyl)methyl]-1-[(2,6-difluorophenyl)methyl]-3-[2-[methyl(2-pyridin-2-ylethyl)amino]ethyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-2,4-dione

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

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Professor in Department of Pharmacy
National University of Singapore, Singapore

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