CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12931
Family Name P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2-chloro-5-(piperazin-1-ylmethyl)benzamide family
No. of Seeds 3 No. of Other Members 1
Family Centroid CFAMM00419093 Functional Category Bioactive
Superfamily P2X purinoceptor 7 and Menin Binder Superfamily
Class Class 3116

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family 5 255
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Acetylcholinesterase Inhibitor Ambenonium Family 4 71
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Neuromedin-K receptor Ligand Osanetant Family 38 192
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
Bavisant family 9 65
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Prothrombin Inhibitor D-leucyl-n-(3-chlorobenzyl)-l-prolinamid... 18 168
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Dipeptidyl peptidase 4 Inhibitor N4-(4-chlorobenzyl)-2,4-diami... 10 22
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3'... 14 11
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 1 1
C-C chemokine receptor type 5 ligand N-[(1S)-3-[(3aS,6aR)-5-(2... 1 1
Coagulation factor X inhibitor 3-amino-4-chloro-N-[(1R)-2-[4-(... 1 1
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-5-amino-2-c... 3 4
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2,5-dichlor... 3 4
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2-amino-6-c... 1 0
Pyruvate kinase PKM and Huntingtin inhibitor CHEMBL1455935 family 1 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 2
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 2 0
Prelamin-A/C and Ras-related protein Rab-9A inhibitor CHEMBL15... 1 7
Prothrombin inhibitor AGN-PC-09QJ23 family 2 5
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 7 31
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 7 16
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... 4 9
Vasopressin V1a receptor ligand N-[(2R)-3-(4-chlorophenyl)-1-[... 6 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075C6K ... 3 22
Melanin-concentrating hormone receptor 1 ligand 1-(3-acetyl-1,... 8 4
Lysosomal Pro-X carboxypeptidase inhibitor (2S,3S)-2-[(2-amino... 3 3
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (3R... 6 1
Sodium-dependent serotonin transporter and Sodium-dependent do... 6 3
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 8 4
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 4
P2X purinoceptor 7 inhibitor (2S)-N-[[2-chloro-3-(trifluoromet... 3 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
C-C chemokine receptor type 1 ligand 4-chloro-N-[(2R)-1-[(4S)-... 6 3
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1
Sodium-dependent dopamine transporter and Transporter inhibito... 6 0
Substance-P receptor ligand SureCN8936495 family 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 9
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 1
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2-chloro-5-... 3 1
Aldose reductase inhibitor SureCN8804611 family 2 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 2,6-d... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00419093 CHEMBL235789 Bioactive N-(1-adamantylmethyl)-2-chloro-5-(piperazin-1-ylmethyl)benzamide
CFAMM00419092 CHEMBL392559 Bioactive N-(1-adamantylmethyl)-2-chloro-5-[[(1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27264 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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