CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12940
Family Name Hydroxycarboxylic acid receptor 2 and Cytochrome P450 2C9 ligand AGN-PC-00CRA4 family
No. of Seeds 2 No. of Other Members 6
Family Centroid CFAMM00419179 Functional Category Bioactive
Superfamily Androgen receptor and Histone deacetylase Binder Superfamily
Class Class 456

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Dolasetron Family 12 171
Neuromedin-K receptor Ligand Talnetant Family 3 49
Retinoic acid receptor alpha Ligand LG100268 Family 2 33
Coagulation factor X Inhibitor Otamixaban Family 9 21
Dihydroorotate dehydrogenase Inhibitor Cinchoninic Acid Family 1 21
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
E3 ubiquitin-protein ligase Mdm2 Inhibitor NSC-66811 Family 4 27
Transient receptor potential cation channel subfamily V member... 6 23
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Renin Inhibitor CP-305202 Family 9 30
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Beta-ketoacyl-acyl carrier protein synthase III Inhibitor 2-[3... 1 2
Coagulation factor X inhibitor (2S)-(3'-AMIDINO-3-BIPHENYL)-5-... 1 0
Prostaglandin E2 receptor EP4 subtype and Prostaglandin D2 rec... 8 17
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 3 28
Vascular endothelial growth factor receptor 2 ligand AGN-PC-05... 2 2
Retinoic acid receptor alpha and Retinoic acid receptor beta l... 1 2
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor AG... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4S,... 5 2
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 3 1
Rho-associated protein kinase 2 and Rho-associated protein kin... 1 3
Egl nine homolog 1 inhibitor 2-[5-methyl-6-[[1-oxo-2-(4-phenyl... 4 3
D(4) dopamine receptor ligand AGN-PC-00SXAZ family 2 4
Rho-associated protein kinase 2 inhibitor 2-hydroxyethyl 3-[2-... 2 0
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 4 0
Beta-3 adrenergic receptor ligand SureCN5704018 family 4 1
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 5
Hydroxycarboxylic acid receptor 2 ligand AGN-PC-04RSPS family 4 0
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 1 1
Integrase inhibitor AC1LARQ6 family 1 2
Retinoic acid receptor alpha and Retinoic acid receptor beta l... 1 0
ATP-sensitive inward rectifier potassium channel 11 ligand N-[... 1 1
ATP-dependent molecular chaperone HSP82 and Arachidonate 12-li... 1 2
Streptokinase A and Nuclear receptor ROR-gamma ligand N-[(2,4-... 4 0
Integrase inhibitor AGN-PC-00F9UX family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00419179 CHEMBL235952 Bioactive AGN-PC-00CRA4
CFAMM00419183 CHEMBL474903 Bioactive aminophenol analogue, 10

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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