CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12941
Family Name Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activator 1 inhibitor SureCN14582199 family
No. of Seeds 4 No. of Other Members 4
Family Centroid CFAMM00419195 Functional Category Bioactive
Superfamily Metabotropic glutamate receptor 1 and Metabotropic glutamate receptor 5 Binder Superfamily
Class Class 3795

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
Cathepsin B and Cathepsin K Inhibitor L-006235-1 Family 19 75
Histone deacetylase 1 Inhibitor N-hydroxy-5-(pyridin-3-yl)thio... 9 46
Cyclin-dependent kinase 5 Inhibitor 3-(2-phenylthiazol-4-yl)qu... 2 44
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Peroxisome proliferator-activated receptor alpha and Peroxisom... 4 8
Cysteine protease and Cruzipain inhibitor N-[(E,3S)-1-(benzene... 1 1
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor lig... 2 8
Coagulation factor X and Prothrombin inhibitor SureCN763988 fa... 31 86
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 13
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QJ7P family 2 0
Neuromedin-K receptor ligand 3-methylsulfinyl-N-[(1S)-1-phenyl... 3 5
Metabotropic glutamate receptor 1 ligand AGN-PC-0A9TG5 family 11 10
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Neuronal acetylcholine receptor subunit alpha-7 ligand AGN-PC-... 7 1
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 8 5
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 9 16
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 8 4
Vascular endothelial growth factor receptor 1 and Receptor-typ... 1 0
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 9 5
Serine/threonine-protein kinase Chk1 inhibitor 2-(1H-indol-5-y... 2 2
D(3) dopamine receptor and D(2) dopamine receptor ligand [4-[2... 6 5
Histone deacetylase 1 inhibitor 5-[5-[[(2-chlorophenyl)methyla... 4 1
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 4 0
Platelet-activating factor receptor ligand N,N-diethyl-3-[(4R)... 11 0
Gamma-aminobutyric acid receptor subunit alpha-2 and Gamma-ami... 6 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 7 2
Epidermal growth factor receptor and Vascular endothelial grow... 14 19
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 1 4
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 1 17
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 6-(b... 1 0
Coagulation factor X inhibitor SureCN1253902 family 2 0
Metabotropic glutamate receptor 5 ligand 2-(2-pyridin-3-ylethy... 1 2
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 1 0
Metabotropic glutamate receptor 5 ligand N-[(2R)-3-hydroxy-3-m... 1 0
Fatty-acid amide hydrolase 1 inhibitor quinoxaline analogue, 1... 1 0
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-04XJR1 family 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00419192 CHEMBL235963 Bioactive SureCN5463834
CFAMM00419191 CHEMBL239636 Bioactive SureCN5469452
CFAMM00419196 CHEMBL241116 Bioactive SureCN5469200
CFAMM00419195 CHEMBL236996 Bioactive SureCN14582199

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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