CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12947
Family Name Sodium-dependent serotonin transporter and Histamine H3 receptor ligand AGN-PC-04US5U family
No. of Seeds 7 No. of Other Members 0
Family Centroid CFAMM00419249 Functional Category Bioactive
Superfamily Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Inhibitor 2-(2-((benzylamino)methyl)phenoxy)-5-chlorophenol Superfamily
Class Class 3034

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Substance-P receptor Ligand Ezlopitant Family 10 207
Acolbifene family 10 115
Dapoxetine family 3 40
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 2 5
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Extracellular calcium-sensing receptor Ligand Nps 568 Family 5 54
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... 4 31
Dipeptidyl peptidase 4 Inhibitor (2-chloro-6-phenoxyphenyl)met... 17 24
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
C-C chemokine receptor type 5 Ligand N-(2-(4-chlorobenzyloxy)-... 3 13
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Inhibitor 2... 1 9
D(4) dopamine receptor ligand AGN-PC-0073PO family 7 10
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 2 3
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[2-... 6 15
5-hydroxytryptamine receptor 1A and Sodium-dependent noradrena... 5 4
Sodium-dependent serotonin transporter and Sodium-dependent no... 6 21
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Beta-secretase 1 and Cathepsin D inhibitor N-[(2S,3R)-1-(3,5-d... 10 15
Histamine H3 receptor ligand AGN-PC-0765YW family 1 4
Sodium-dependent noradrenaline transporter and Sodium-dependen... 14 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 3 7
Sodium-dependent serotonin transporter and Histamine H3 recept... 4 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 13 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Sodium-dependent serotonin transporter inhibitor 4-(4-chloro-2... 2 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 1 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 0
Substance-P receptor ligand SureCN6400808 family 2 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 2
D(4) dopamine receptor ligand 4-[(4-chlorophenyl)methyl]-2-[(2... 1 0
Putative NP ZINC04061066 Family 18 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00419249 CHEMBL236475 Bioactive AGN-PC-04US5U
CFAMM00419248 CHEMBL397577 Bioactive AGN-PC-04USYU
CFAMM00419247 CHEMBL397575 Bioactive AGN-PC-04USFL
CFAMM00419246 CHEMBL236675 Bioactive AGN-PC-04US5W

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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