CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12954
Family Name Glucocorticoid receptor ligand 1,1,1-trifluoro-2-[(1-methyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]-3-(quinolin-5-ylamino)propan-2-ol family
No. of Seeds 5 No. of Other Members 0
Family Centroid CFAMM00419291 Functional Category Bioactive
Superfamily Glucocorticoid receptor and 5-hydroxytryptamine receptor 1D Binder Superfamily
Class Class 2748

Cousin Family NamesSeedsMembers
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Progesterone receptor and Glucocorticoid receptor ligand SureC... 4 2
Glucocorticoid receptor ligand 4-fluoro-2-[5,5,5-trifluoro-4-h... 3 9
Glucocorticoid receptor ligand 1,1,1-trifluoro-2-[(1-methyl-3,... 3 4
Glucocorticoid receptor ligand 2-[2-[(1-ethyl-3,4-dihydro-2H-n... 2 0


External ID

Functional Category

Molecule Name

CFAMM00419291 CHEMBL393551 Bioactive 1,1,1-trifluoro-2-[(1-methyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]-3-(quinolin-5-ylamino)propan-2-ol
CFAMM00419290 CHEMBL393349 Bioactive 1,1,1-trifluoro-2-[(isoquinolin-5-ylamino)methyl]-3-(1-methyl-3,4-dihydro-2H-naphthalen-1-yl)propan-2-ol
CFAMM00419289 CHEMBL238360 Bioactive 1,1,1-trifluoro-2-[(1-methyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]-3-[(2-methylquinolin-5-yl)amino]propan-2-ol
CFAMM00419288 CHEMBL238147 Bioactive 2-[(1-ethyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]-1,1,1-trifluoro-3-[(2-methylquinolin-5-yl)amino]propan-2-ol
CFAMM00419287 CHEMBL236229 Bioactive 2-[(1-ethyl-3,4-dihydro-2H-naphthalen-1-yl)methyl]-1,1,1-trifluoro-3-(isoquinolin-5-ylamino)propan-2-ol

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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