CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12996
Family Name Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-chlorophenyl)-1-propan-2-ylpyrrolidine-3-carbonyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]-3-(dimethylamino)propanamide family
No. of Seeds 26 No. of Other Members 13
Family Centroid CFAMM00419514 Functional Category Bioactive with Natural Product
Superfamily Melanocortin receptor 4 and Cannabinoid receptor 1 Binder Superfamily
Class Class 1375

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
Motilin receptor Ligand GSK962040 Family 30 457
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Integrin alpha-4 Inhibitor BIO-1211 Family 16 83
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 19 186
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Prothrombin Inhibitor D-leucyl-n-(3-chlorobenzyl)-l-prolinamid... 18 168
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 19 88
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Bifunctional epoxide hydrolase 2 Inhibitor N-(3-chloro-phenyl)... 2 43
Cannabinoid receptor 1 Ligand 1,3,5-triphenylimidazolidine-2,4... 2 17
Cannabinoid receptor 1 Ligand 1-(bis(4-chlorophenyl)methyl)-3-... 4 44
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Leukotriene A-4 hydrolase Inhibitor N5-[4-benzylphenyl]-l-glut... 2 1
Phospholipase D1 Inhibitor Halopemide Family 17 111
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 1 1
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Cruzipain Inhibitor N1,n4-bis(5-chloro-2-methylphenyl)succinam... 1 5
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
D(4) dopamine receptor and D(2) dopamine receptor ligand methy... 2 11
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZBI0 family 2 16
D(4) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 1 0
Substance-K receptor and Substance-P receptor ligand N-[4-[[4-... 1 4
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
E3 ubiquitin-protein ligase Mdm2 inhibitor (2'R,3R,3'S,5'S)-6-... 17 51
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 15 12
Melanocortin receptor 4 ligand tert-butyl 4-[(3S)-4-[4-[2-[1-[... 2 6
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
Coagulation factor X inhibitor 3-amino-4-chloro-N-[(1R)-2-[4-(... 1 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 6 6
Neuropeptide Y receptor type 2 ligand N-[3-chloro-4-[2-(cyclop... 1 2
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 6
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
D(3) dopamine receptor and Alpha-1B adrenergic receptor ligand... 11 8
Substance-P receptor ligand (2S,4S)-2-N-[3-(diethylamino)propy... 2 7
Cellular tumor antigen p53 and Inositol monophosphatase 1 inhi... 1 12
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 7 31
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 7 16
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 5 37
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... 4 9
Dipeptidyl peptidase 8 inhibitor (2S)-2-amino-4-[4-[bis(4-fluo... 2 9
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 6 9
Neuropeptide Y receptor type 5 ligand 2-(6-chloro-3,4-dihydro-... 5 1
Melanin-concentrating hormone receptor 1 ligand 4-(4-chlorophe... 2 0
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
Melanin-concentrating hormone receptor 1 ligand SureCN3845324 ... 7 4
Melanocortin receptor 4 and Melanocortin receptor 5 ligand 3-[... 18 26
Lysosomal Pro-X carboxypeptidase inhibitor (2S,3S)-2-[(2-amino... 3 3
Dipeptidyl peptidase 4 inhibitor SureCN296150 family 3 8
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 2 1
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
D(3) dopamine receptor and D(2) dopamine receptor ligand RGH-1... 8 0
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (3R... 7 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (3R... 6 1
Melanin-concentrating hormone receptor 1 ligand SureCN14265866... 11 2
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 8 4
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 2
Melanocortin receptor 4 ligand SureCN6183720 family 2 5
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 3 0
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 5 2
Growth hormone secretagogue receptor type 1 ligand N-[4,6-dich... 2 0
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(cyanomethyl)-... 1 6
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 4
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 14 5
P2X purinoceptor 7 inhibitor SureCN3726471 family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-088GOO family 3 0
P2X purinoceptor 7 inhibitor SureCN3652462 family 5 2
P2X purinoceptor 7 inhibitor SureCN3721807 family 3 0
Translocator protein inhibitor CHEMBL2332254 family 6 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 3
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1
Nociceptin receptor and Delta-type opioid receptor ligand spir... 25 9
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(2R,3R)-3-(4-c... 1 0
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 6 0
Urotensin-2 receptor and Cytochrome P450 2D6 ligand 2-[3,4-dic... 2 3
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(3... 2 4
Kappa-type opioid receptor and Urotensin-2 receptor ligand 2-(... 5 1
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
5-hydroxytryptamine receptor 7 ligand 7-chloro-3-[4-[4-(4-chlo... 2 0
Mu-type opioid receptor and Nociceptin receptor ligand SureCN8... 7 1
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 1 1
Substance-K receptor and Neuromedin-K receptor ligand 1-benzyl... 3 10
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 4 2
Glutamate receptor ionotropic, NMDA 1 ligand CHEMBL40730 family 4 1
Sodium-dependent dopamine transporter and Transporter inhibito... 6 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 4 1
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 5
Sodium-dependent noradrenaline transporter inhibitor AGN-PC-07... 1 1
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 1 5
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
Progesterone receptor ligand CHEMBL403139 family 2 0
Melanocortin receptor 4 ligand 2-amino-N-[(2R)-3-(2,4-dichloro... 5 5
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 9
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 1
C-C chemokine receptor type 1 ligand (2R)-2-N-[(4-chlorophenyl... 1 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 0
Calcitonin gene-related peptide type 1 receptor and Dual speci... 4 0
Neuropeptide Y receptor type 5 ligand SureCN6214451 family 3 1
72 kDa type IV collagenase and Disintegrin and metalloproteina... 1 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 0
Potassium voltage-gated channel subfamily H member 2 and D(3) ... 3 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 3 4
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 0
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide de... 2 4
C-C chemokine receptor type 3 ligand 4-[[2-(4-chlorophenyl)eth... 4 2
Melanocortin receptor 4 ligand N-[(1S)-1-[5-chloro-2-[4-[(2S,3... 2 5
Aldose reductase inhibitor Spiro-cimqat family 6 8
C5a anaphylatoxin chemotactic receptor 1 ligand SureCN12047568... 1 1
Acyl-CoA:cholesterol acyltransferase inhibitor N-[2,6-di(propa... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00419524 CHEMBL236872 Bioactive 1-[(2S)-1-[4-[2-[(1S)-1-amino-3-methylbutyl]-4-(trifluoromethyl)phenyl]piperazin-1-yl]-3-(4-chlorophenyl)-1-oxopropan-2-yl]pyrrolidin-2-one
CFAMM00419537 CHEMBL402058 Bioactive N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-chlorophenyl)-1-propan-2-ylpyrrolidine-3-carbonyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]-2-(dimethylamino)acetamide
CFAMM00419543 CHEMBL270015 Bioactive N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-chlorophenyl)pyrrolidine-3-carbonyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]-3-(dimethylamino)propanamide
CFAMM00419536 CHEMBL402787 Bioactive N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-chlorophenyl)-1-propanoylpyrrolidine-3-carbonyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]-3-(dimethylamino)propanamide
CFAMM00419529 CHEMBL255099 Bioactive 1-[(2R,3R)-2-[4-[2-[(1S)-1-amino-2-methylpropyl]-4-methylphenyl]piperazine-1-carbonyl]-3-(4-chlorophenyl)pyrrolidin-1-yl]-2,2-dimethylpropan-1-one
CFAMM00419542 CHEMBL406309 Bioactive N-[(1S)-1-[2-[4-[(3S,4R)-1-acetyl-4-(4-chlorophenyl)pyrrolidine-3-carbonyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]-3-(dimethylamino)propanamide
CFAMM00419509 CHEMBL402017 Bioactive N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-chlorophenyl)-1-(oxan-4-yl)pyrrolidine-3-carbonyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]-2-(methylamino)acetamide
CFAMM00419535 CHEMBL439387 Bioactive [4-[2-[(1S)-1-amino-2-methylpropyl]-4-methylphenyl]piperazin-1-yl]-[(3S,4R)-4-(4-chlorophenyl)-1-cyclohexylpyrrolidin-3-yl]methanone
CFAMM00419515 CHEMBL400934 Bioactive N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-chlorophenyl)-1-propan-2-ylpyrrolidine-3-carbonyl]piperazin-1-yl]-5-(trifluoromethyl)phenyl]-3-methylbutyl]-2-(methylamino)acetamide
CFAMM00419541 CHEMBL396660 Bioactive [4-[2-[(1S)-1-amino-2-methylpropyl]-4-methylphenyl]piperazin-1-yl]-[(3S,4R)-4-(4-chlorophenyl)-1-[1-(2-methylpropyl)piperidin-4-yl]pyrrolidin-3-yl]methanone
CFAMM00419528 CHEMBL404549 Bioactive (2S)-2-amino-N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-chlorophenyl)-1-(oxan-4-yl)pyrrolidine-3-carbonyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]propanamide
CFAMM00419521 CHEMBL404503 Bioactive (2R,3R)-2-[4-[2-[(1S)-1-amino-2-methylpropyl]-4-methylphenyl]piperazine-1-carbonyl]-3-(4-chlorophenyl)-N,N-dimethylpyrrolidine-1-carboxamide
CFAMM00419534 CHEMBL249571 Bioactive (2R)-2-amino-N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-chlorophenyl)-1-propan-2-ylpyrrolidine-3-carbonyl]piperazin-1-yl]-5-(trifluoromethyl)phenyl]-3-methylbutyl]propanamide
CFAMM00419514 CHEMBL400932 Bioactive N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-chlorophenyl)-1-propan-2-ylpyrrolidine-3-carbonyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]-3-(dimethylamino)propanamide
CFAMM00419540 CHEMBL429314 Bioactive [(3S,4R)-4-(4-chlorophenyl)-1-(oxan-4-yl)pyrrolidin-3-yl]-[4-[2-[(1S)-1-(dimethylamino)-2-methylpropyl]-4-methylphenyl]piperazin-1-yl]methanone
CFAMM00419520 CHEMBL256686 Bioactive (2R)-2-amino-N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-chlorophenyl)-1-(oxan-4-yl)pyrrolidine-3-carbonyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]propanamide
CFAMM00419533 CHEMBL402060 Bioactive N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-chlorophenyl)-1-propan-2-ylpyrrolidine-3-carbonyl]piperazin-1-yl]-5-(trifluoromethyl)phenyl]-3-methylbutyl]azetidine-3-carboxamide
CFAMM00419513 CHEMBL400933 Bioactive 2-amino-N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-chlorophenyl)-1-propan-2-ylpyrrolidine-3-carbonyl]piperazin-1-yl]-5-(trifluoromethyl)phenyl]-3-methylbutyl]acetamide
CFAMM00419539 CHEMBL272956 Bioactive 3-amino-N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-chlorophenyl)-1-(oxan-4-yl)pyrrolidine-3-carbonyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]propanamide
CFAMM00419532 CHEMBL248435 Bioactive N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-chlorophenyl)-1-propan-2-ylpyrrolidine-3-carbonyl]piperazin-1-yl]-5-(trifluoromethyl)phenyl]-3-methylbutyl]-3-(dimethylamino)propanamide
CFAMM00419518 CHEMBL402043 Bioactive 3-amino-N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-chlorophenyl)-1-propan-2-ylpyrrolidine-3-carbonyl]piperazin-1-yl]-5-(trifluoromethyl)phenyl]-3-methylbutyl]propanamide
CFAMM00419531 CHEMBL404069 Bioactive 2-amino-N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-chlorophenyl)-1-(oxan-4-yl)pyrrolidine-3-carbonyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45918 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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