CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12998
Family Name 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R,6S)-6-[(E)-2-[2-(4-fluoro-3,5-dimethylphenyl)-4,6-dimethylphenyl]ethenyl]-4-hydroxyoxan-2-one family
No. of Seeds 2 No. of Other Members 15
Family Centroid CFAMM00419577 Functional Category Bioactive
Superfamily 3-hydroxy-3-methylglutaryl-coenzyme A reductase Binder Superfamily 4
Class Class 606

Cousin Family NamesSeedsMembers
Collagenase 3 and Macrophage metalloelastase Inhibitor 5-(4'-c... 4 43
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R,... 3 23
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R)... 1 9
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor [(1S... 2 9
NP 3,3,5,5-tetramethyl-6-(phenylethynyl)dihydro-2h-pyran-2,4(3... 6 3


External ID

Functional Category

Molecule Name

CFAMM00419571 CHEMBL440891 Bioactive L 645164
CFAMM00419577 CHEMBL2368968 Bioactive (4R,6S)-6-[(E)-2-[2-(4-fluoro-3,5-dimethylphenyl)-4,6-dimethylphenyl]ethenyl]-4-hydroxyoxan-2-one

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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