CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13017
Family Name Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-5-(diaminomethylideneamino)-2-[[(6S,14S,19R,22S,25S,28S,34S,37S)-6,11,14-triamino-28-(carboxymethyl)-22,34-bis[3-(diaminomethylideneamino)propyl]-25-[(4-methoxyphenyl)methyl]-2,5,13,21,24,27,30,33,36-nonaoxospiro[16,17-dithia-1,4,10,12,20,23,26,29,32,35-decazabicyclo[35.3.0]tetracont-10-ene-15,1'-cyclohexane]-19-carbonyl]amino]pentanoic acid family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00419674 Functional Category Bioactive
Superfamily Integrin beta-3 and Integrin alpha-IIb Binder Superfamily 13
Class Class 590

Cousin Family NamesSeedsMembers
Vasopressin V2 receptor ligand peptide analog Desmopressin family 111 1472
Trypsin inhibitor polypeptide Aprotinin Family 7 68
Oxytocin receptor Ligand Oxytocin Family 30 182
Glucan synthesis regulatory protein Inhibitor Caspofungin Family 17 71
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Growth hormone-releasing hormone receptor ligand polypeptide ... 14 34
Thymopentin family 20 133
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Plitidepsin family 15 5
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
Plasmepsin-2 Inhibitor KNI-727 Family 3 37
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Proto-oncogene tyrosine-protein kinase Src Inhibitor Glu-pro-g... 8 4
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Proto-oncogene tyrosine-protein kinase Src Inhibitor Y-c[d-pen... 20 66
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Mu-type opioid receptor and Nociceptin receptor Ligand Ac-ryyr... 60 11
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
C-X-C chemokine receptor type 4 Ligand Cyclo(-d-tyr-l-ala-l-ar... 25 23
Prothrombin Inhibitor Cyclotheonamide E5 Family 3 0
Integrin alpha-V Inhibitor C[rgdf-(3s)-carboxymorpholine] Family 10 2
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Vasopressin V1a receptor Ligand Vasopressin Analogue Family 4 3
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Glutamate receptor ionotropic, kainate 2 ligand (2S,3S,4S)-4-[... 4 10
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(4S)-3... 3 24
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6453971 f... 3 4
Pol polyprotein inhibitor MDL 74538 family 11 1
NS3 inhibitor CHEMBL201121 family 1 4
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Vasopressin V1a receptor and Vasopressin V1b receptor ligand C... 6 0
Angiotensin-converting enzyme 2 and Neprilysin inhibitor (2S)-... 6 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-me... 4 0
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Angiotensin-converting enzyme inhibitor (2S,4S)-1-[(2S)-2-meth... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00419675 CHEMBL450284 Bioactive AGN-PC-074HZR
CFAMM00419674 CHEMBL2371536 Bioactive (2S)-5-(diaminomethylideneamino)-2-[[(6S,14S,19R,22S,25S,28S,34S,37S)-6,11,14-triamino-28-(carboxymethyl)-22,34-bis[3-(diaminomethylideneamino)propyl]-25-[(4-methoxyphenyl)methyl]-2,5,13,21,24,27,30,33,36-nonaoxospiro[16,17-dithia-1,4,10,12,20,23,26,29,32,35-decazabicyclo[35.3.0]tetracont-10-ene-15,1'-cyclohexane]-19-carbonyl]amino]pentanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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