CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1303
Family Name 5-hydroxytryptamine receptor 6 ligand N-[3-[[(2R)-1-methylpyrrolidin-2-yl]methyl]-1H-indol-5-yl]-4-(trifluoromethoxy)benzenesulfonamide family
No. of Seeds 6 No. of Other Members 0
Family Centroid CFAMM00321741 Functional Category Bioactive
Superfamily 5-hydroxytryptamine receptor 6 and Cytochrome P450 3A4 Binder Superfamily 3
Class Class 44

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Serine/threonine-protein kinase PLK1 Inhibitor HMN-214 Family 3 58
Prostaglandin E2 receptor EP2 subtype Ligand CP-533536 Family 2 9
Apricoxib family 8 77
Indeglitazar family 3 39
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 3
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Prostaglandin G/H synthase 2 Inhibitor 5-methoxy-2-(4-(methyls... 3 12
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 5
Cannabinoid receptor 2 ligand AGN-PC-09M5M9 family 1 0
5-hydroxytryptamine receptor 6 ligand SureCN5502542 family 4 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 15
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Progesterone receptor and Androgen receptor ligand AGN-PC-04QD... 1 0
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 2 0
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
5-hydroxytryptamine receptor 6 ligand CHEMBL1950763 family 1 1
5-hydroxytryptamine receptor 6 ligand SureCN5253197 family 4 2
5-hydroxytryptamine receptor 6 ligand 9-(4-methoxyphenyl)sulfo... 1 0
5-hydroxytryptamine receptor 6 ligand 1-(2-bromo-4-methoxyphen... 2 1
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Neutrophil collagenase and Stromelysin-1 inhibitor (3R)-N-hydr... 2 0
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 6 ligand 1-[9-(2,5-dimethoxypheny... 2 0
5-hydroxytryptamine receptor 6 ligand AGN-PC-075BWR family 1 1
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-difluo... 3 3
Oxytocin receptor and Vasopressin V1a receptor ligand 4-methox... 9 8
Prostaglandin E2 receptor EP3 subtype ligand (E)-3-(1-methyl-4... 14 12
Protein kinase C theta type and Protein kinase C delta type in... 10 7
5-hydroxytryptamine receptor 6 and Cytochrome P450 3A4 ligand ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00321743 CHEMBL609993 Bioactive N-[3-[[(2R)-pyrrolidin-2-yl]methyl]-1H-indol-5-yl]-4-(trifluoromethoxy)benzenesulfonamide
CFAMM00321741 CHEMBL606548 Bioactive N-[3-[[(2R)-1-methylpyrrolidin-2-yl]methyl]-1H-indol-5-yl]-4-(trifluoromethoxy)benzenesulfonamide
CFAMM00321740 CHEMBL606816 Bioactive N-[3-[[(2S)-1-methylpyrrolidin-2-yl]methyl]-1H-indol-5-yl]-4-(trifluoromethoxy)benzenesulfonamide
CFAMM00321745 CHEMBL578023 Bioactive 2-[[(1Z)-1-[5-[(4-methoxyphenyl)sulfonylamino]indol-3-ylidene]ethyl]amino]guanidine
CFAMM00321744 CHEMBL606558 Bioactive 4-methoxy-N-[3-[[(2R)-1-methylpyrrolidin-2-yl]methyl]-1H-indol-5-yl]benzenesulfonamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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