CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13044
Family Name Tyrosine-protein kinase ABL1 and Breakpoint cluster region protein inhibitor N-[4-[2-(dimethylamino)ethoxy]phenyl]-4-methoxy-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide family
No. of Seeds 8 No. of Other Members 5
Family Centroid CFAMM00419966 Functional Category Bioactive
Superfamily Renin and Insulin-like growth factor 1 receptor Binder Superfamily
Class Class 1070

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Epidermal growth factor receptor and Receptor tyrosine-protein... 16 89
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
Smoothened homolog Inhibitor LDE225 Family 3 76
AP26113 family 16 90
SB1518 family 7 103
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
MK-6096 family 3 69
JAK Inhibitor Momelotinib Family 33 83
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lyn and Tyrosine-protein kinase Lck in... 1 6
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 11
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 9 3
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Hepatocyte growth factor receptor ligand SureCN4492034 family 2 2
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 2 3
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 6 47
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Aurora kinase A inhibitor AGN-PC-00BCUF family 16 43
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 0
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Inositol monophosphatase 1 inhibitor CHEMBL1588383 family 1 6
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 2
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Insulin receptor and Insulin-like growth factor 1 receptor lig... 17 7
Insulin-like growth factor 1 receptor and Potassium voltage-ga... 2 2
Dihydrofolate reductase inhibitor 3-(2,4-diamino-6-methylquina... 2 1
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 3 0
Platelet-derived growth factor receptor beta and Receptor-type... 5 1
Insulin-like growth factor 1 receptor ligand GSK1220512A family 20 15
Proto-oncogene tyrosine-protein kinase Src and Vascular endoth... 7 3
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(... 9 3
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[(1... 2 0
Protein-tyrosine kinase 2-beta and Focal adhesion kinase 1 inh... 3 6
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
MAP kinase-activated protein kinase 2 inhibitor 4-[5-[4-(4-pip... 1 11
Aurora kinase A inhibitor AGN-PC-0760BB family 1 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Epidermal growth factor receptor ligand SureCN4454332 family 18 5
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 3 5
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
G-protein coupled bile acid receptor 1 ligand 2-ethyl-6-[3-[4-... 4 6
Motilin receptor ligand SureCN2765637 family 1 1
Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... 2 0
Metabotropic glutamate receptor 5 ligand AGN-PC-0DB8TJ family 2 0
Angiopoietin-1 receptor ligand SureCN1939461 family 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... 8 1
Orexin receptor type 1 and Orexin receptor type 2 ligand (1R,2... 6 1
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Metabotropic glutamate receptor 5 and Cytochrome P450 3A4 liga... 3 7
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Ephrin type-A receptor 3 and Tyrosine-protein kinase Fgr ligan... 1 3
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 2
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-(3-c... 3 3
Receptor tyrosine-protein kinase erbB-2 ligand SureCN3374869 f... 4 8
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 1
Mitogen-activated protein kinase 14 inhibitor SureCN4913214 fa... 1 2
Epidermal growth factor receptor ligand AGN-PC-078X8C family 10 8
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 0
Gonadotropin-releasing hormone receptor ligand 2-tert-butyl-8-... 6 23
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Nuclear receptor ROR-gamma and Prelamin-A/C ligand ST50133141 ... 1 0
Gonadotropin-releasing hormone receptor ligand 4-[2-[(2S)-azet... 1 0
Adenosine kinase inhibitor AGN-PC-0757MS family 2 0
Tyrosine-protein kinase Lck inhibitor SureCN374434 family 1 1
Tyrosine-protein kinase Lck inhibitor N-(5-tert-butyl-1,2-oxaz... 1 0
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 0
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 15 1
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Cathepsin S and Cathepsin K inhibitor 2-cyano-pyrropyrimidine,... 4 1
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 6 0
Transient receptor potential cation channel subfamily V member... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 10 4
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-071H3F fa... 3 0
Acyl-CoA desaturase inhibitor SureCN1182546 family 2 5
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 19 2
Insulin-like growth factor 1 receptor ligand AGN-PC-07C5TC family 2 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 1 0
Neuropeptide Y receptor type 5 ligand SureCN2658856 family 6 0
Tyrosine-protein kinase receptor Tie-1 and Receptor-type tyros... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-0766EI f... 1 0
Vascular endothelial growth factor receptor 2 and Serine/threo... 4 2
Vascular endothelial growth factor receptor 2 and Serine/threo... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00419969 CHEMBL2375892 Bioactive N-(3-fluorophenyl)-4-methoxy-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide
CFAMM00419962 CHEMBL2375889 Bioactive N-(3-chloro-4-fluorophenyl)-4-methoxy-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide
CFAMM00419967 CHEMBL2375977 Bioactive 4-methoxy-N-[4-(3-morpholin-4-ylpropoxy)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide
CFAMM00419966 CHEMBL2375972 Bioactive N-[4-[2-(dimethylamino)ethoxy]phenyl]-4-methoxy-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide
CFAMM00419965 CHEMBL2375973 Bioactive N-[4-[2-(diethylamino)ethoxy]phenyl]-4-methoxy-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide
CFAMM00419964 CHEMBL2375971 Bioactive N-[4-[3-(dimethylamino)propoxy]phenyl]-4-methoxy-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide
CFAMM00419970 CHEMBL2375891 Bioactive N-(4-bromophenyl)-4-methoxy-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide
CFAMM00419963 CHEMBL2375900 Bioactive 4-methoxy-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]-N-pyrimidin-2-ylbenzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27513 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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