CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13046
Family Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform and Serine/threonine-protein kinase mTOR inhibitor 2-[4-(2-amino-4-methyl-7-oxo-6-quinolin-3-ylpyrido[2,3-d]pyrimidin-8-yl)cyclohexyl]oxyacetamide family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00332202 Functional Category Bioactive
Superfamily Macrophage colony-stimulating factor 1 receptor and Serine/threonine-protein kinase mTOR Binder Superfamily
Class Class 1031

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Serine/threonine-protein kinase mTOR Inhibitor AZD2014 Family 2 41
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 37 10
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 6 Inhibi... 2 3
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Serine/threonine-protein kinase mTOR and RAC-alpha serine/thre... 3 3
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
G1/S-specific cyclin-D1 and G1/S-specific cyclin-D3 inhibitor ... 6 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 1
Transient receptor potential cation channel subfamily V member... 2 1
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 0
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 0
Macrophage colony-stimulating factor 1 receptor and Mast/stem ... 27 4
Epidermal growth factor receptor ligand AGN-PC-073LJS family 4 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
Transient receptor potential cation channel subfamily V member... 3 2
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Glycogen synthase kinase-3 beta inhibitor SureCN13987027 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27518 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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