CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13063
Family Name 5-hydroxytryptamine receptor 6 ligand 2-methyl-5-(2-nitrophenoxy)-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole family
No. of Seeds 1 No. of Other Members 6
Family Centroid CFAMM00420059 Functional Category Bioactive with Natural Product
Superfamily Prelamin-A/C and Niemann-Pick C1 protein Binder Superfamily 5
Class Class 3208

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
DNA Binder Elliptinium Acetate Family 11 116
Apricoxib family 8 77
Indeglitazar family 3 39
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 0
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 2 0
Retinoic acid receptor RXR-alpha ligand (E)-3-[3-(3,5-ditert-b... 5 5
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 2 11
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 4 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00420059 CHEMBL2376488 Bioactive 2-methyl-5-(2-nitrophenoxy)-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27526 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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