CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM131
Family Name Vasopressin V2 receptor and Vasopressin V1a receptor ligand AGN-PC-074T9A family
No. of Seeds 1 No. of Other Members 7
Family Centroid CFAMM00307751 Functional Category Bioactive with Natural Product
Superfamily Histone deacetylase 2 and Metabotropic glutamate receptor 5 Binder Superfamily
Class Class 281

Cousin Family NamesSeedsMembers
D(2) dopamine receptor Ligand Nemonapride Family 70 283
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
Cruzipain Inhibitor 1-(3-methoxy-benzyl)-5-methyl-1h-indole-2,... 2 11
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Oxysterols receptor LXR-alpha Ligand N-{4-[2-(4-methoxyphenyl)... 3 16
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Multidrug resistance protein 1 and Multidrug resistance-associ... 3 55
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
D(2) dopamine receptor Ligand Epidepride Family 31 66
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Metabotropic glutamate receptor 5 Ligand N-(3-(3-cyanobenzamid... 2 13
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
Integrin beta-1 and Integrin alpha-4 inhibitor (3S)-3-(3,4-dim... 5 61
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Microsomal triglyceride transfer protein large subunit inhibit... 4 5
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
Presenilin-1 and Presenilin-2 inhibitor (2S)-3-(3,4-difluoroph... 1 2
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 2
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 7 9
Substance-P receptor ligand (2S,4S)-1-N-(3-chlorophenyl)-2-N-[... 5 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 7
Gastrin/cholecystokinin type B receptor ligand 1-[3-[[2-(3-met... 2 12
C5a anaphylatoxin chemotactic receptor 1 ligand N-[(4-dimethyl... 1 4
Prostaglandin D2 receptor 2 ligand SureCN136287 family 1 9
Trace amine-associated receptor 1 ligand EPPTB family 4 9
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Melanin-concentrating hormone receptor 1 and Potassium voltage... 3 6
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Sphingosine 1-phosphate receptor 1 ligand 2-methoxy-N-[(4-phen... 2 23
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 3
Mitogen-activated protein kinase 14 inhibitor N-[2-fluoro-5-[(... 4 5
Integrin beta-3 and Integrin alpha-2 inhibitor 3-(4-methoxyphe... 4 6
Bifunctional epoxide hydrolase 2 inhibitor SureCN3178516 family 3 1
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-fluoro-5-hydro... 2 0
Neuropeptide Y receptor type 1 ligand SureCN8354018 family 2 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 11
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 7
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 11 4
Neuropeptide Y receptor type 5 ligand 1-[1-(4-fluorophenyl)pro... 2 8
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZ6 family 3 6
Histamine H3 receptor and Potassium voltage-gated channel subf... 28 30
Leukotriene A-4 hydrolase inhibitor SureCN5313952 family 4 1
Growth hormone secretagogue receptor type 1 ligand N-[4-[(2S)-... 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Pol polyprotein inhibitor Phenprocoumon .b.AlaNH deriv. family 1 5
C-C chemokine receptor type 3 ligand SureCN6700764 family 2 2
Caspase-3 inhibitor AGN-PC-00ELYM family 3 2
Histone deacetylase 1 and Histone deacetylase 2 inhibitor Sure... 2 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 1
4,4,6-trimethyl-1,3-dihydroimidazo[1,2-a]indol-2-one NP ZINC02... 37 0
8,10,10-trimethyl-3,4-dihydro-1H-pyrimido[1,2-a]indol-2-one NP... 14 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00307751 CHEMBL102311 Bioactive AGN-PC-074T9A

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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