CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1310
Family Name Neprilysin and Aminopeptidase N inhibitor (2S)-2-[[(2S)-2-[[[amino(phenyl)methyl]-hydroxyphosphoryl]methyl]-3-(4-phenylphenyl)propanoyl]amino]propanoic acid family
No. of Seeds 13 No. of Other Members 1
Family Centroid CFAMM00218406 Functional Category Bioactive
Superfamily Proto-oncogene tyrosine-protein kinase Src Inhibitor RU83876 Superfamily
Class Class 1787

Cousin Family NamesSeedsMembers
Penicillin binding protein inhibitor β-lactam aminopenicillin ... 12 359
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme inhibitor Phosphonate-containing... 7 41
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
Thymopentin family 20 133
Angiotensin-converting enzyme and Neprilysin Inhibitor M100,24... 18 60
Dopamine reuptake Inhibitor Amineptine Family 2 5
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Flovagatran family 12 546
Neprilysin Inhibitor Thiorphan Family 41 68
Prothrombin Inhibitor LB30812 Family 12 36
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU84687 F... 2 14
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU83876 F... 3 51
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Disintegrin and metalloproteinase domain-containing protein 17... 8 7
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Beta-secretase 1 Inhibitor Glu-leu-asp-leu-(choh-ch2)-ala-ala-... 15 11
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Caspase-1 Inhibitor Z-vad-cho Family 8 34
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Delta-type opioid receptor Ligand H-cxp-ala-gly-phe-leu-oh Family 1 8
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-154957 Family 2 3
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Inhibit... 5 23
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Receptor-type tyrosine-protein phosphatase C Ligand Asp-brpmp-... 2 0
Endothelin-converting enzyme 1 Inhibitor PO3 2-leu-nal-o-3k Fa... 3 26
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Genome polyprotein Inhibitor Acasp-glu-dif-glu-cha-cys Family 13 17
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Angiotensin-converting enzyme inhibitor (S)-1-((S)-5-benzamido... 5 2
Pol polyprotein inhibitor benzyl N-[(2S)-1-[[(2S,3S,4R,5S)-3,4... 21 5
Aminopeptidase N and Neprilysin inhibitor (2S)-2-[[(2S)-2-[[[(... 1 0
Carboxypeptidase B and Carboxypeptidase B2 inhibitor (2S)-7-am... 3 9
Renin and Cathepsin D inhibitor (3S)-4-[[6-acetamido-2-[[3-nap... 6 26
Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73
Endothelin-converting enzyme 1 and Neprilysin inhibitor (2S)-2... 1 8
Neprilysin inhibitor SureCN489232 family 3 9
Growth factor receptor-bound protein 2 ligand 2-[(9S,10S,11E,1... 5 14
Matrix metalloproteinase-9 inhibitor (3R)-2-[ethoxy-(4-phenylp... 4 15
Growth factor receptor-bound protein 2 ligand [4-[[(2S,5S,9S,1... 2 1
Endothelin-converting enzyme 1 and Cathepsin D inhibitor N-[(2... 6 2
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 5 3
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2S,4R)... 5 8
Angiotensin-converting enzyme inhibitor (2S,4R)-1-[(2S)-6-amin... 3 1
Neprilysin inhibitor SureCN7437961 family 2 6
Collagenase 3 and Interstitial collagenase inhibitor (4-benzyl... 2 0
Tyrosine-protein phosphatase non-receptor type 1 and Tyrosine-... 1 1
Histone deacetylase 1 and Histone deacetylase 8 inhibitor meth... 1 3
Neprilysin inhibitor AGN-PC-075S5F family 1 1
Angiotensin-converting enzyme and Neprilysin inhibitor (2S)-2-... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 6
Neutrophil collagenase and Macrophage metalloelastase inhibito... 1 0
Gamma-secretase subunit PEN-2 inhibitor SureCN5966881 family 1 9
Endothelin-converting enzyme 1 and Neprilysin inhibitor [[(2S)... 2 2
Aminopeptidase N and Cytosol aminopeptidase inhibitor AGN-PC-0... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00322067 CHEMBL1159942 Bioactive (2S)-2-[[(2S)-2-[[[(S)-amino(phenyl)methyl]-hydroxyphosphoryl]methyl]-3-(4-phenylphenyl)propanoyl]amino]propanoic acid
CFAMM00322073 CHEMBL36588 Bioactive AGN-PC-01ZIS1
CFAMM00322072 CHEMBL341868 Bioactive (2S)-2-phenyl-2-[[3-(4-phenylphenyl)-2-(phosphonomethylamino)propanoyl]amino]acetic acid
CFAMM00322071 CHEMBL1159923 Bioactive (2S)-2-[[(2S)-2-[[[amino(phenyl)methyl]-hydroxyphosphoryl]methyl]-3-phenylpropanoyl]amino]-2-phenylacetic acid
CFAMM00322070 CHEMBL117394 Bioactive (2S)-2-[[(2R)-2-[[[(S)-amino(phenyl)methyl]-hydroxyphosphoryl]methyl]-3-(4-phenylphenyl)propanoyl]amino]propanoic acid
CFAMM00322069 CHEMBL1159953 Bioactive (2S)-2-[[(2S)-2-[[[(S)-amino(phenyl)methyl]-hydroxyphosphoryl]methyl]-3-(4-phenylphenyl)propanoyl]amino]-3-hydroxypropanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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