CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13121
Family Name Serine/threonine-protein kinase Chk1 inhibitor 2-(1,3-dihydroisoindol-2-yl)-N-(4-piperazin-1-ylpyridin-3-yl)-1,3-thiazole-4-carboxamide family
No. of Seeds 2 No. of Other Members 5
Family Centroid CFAMM00420534 Functional Category Bioactive
Superfamily Tyrosine-protein kinase SYK and Neuropeptide Y receptor type 5 Binder Superfamily
Class Class 1642

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Cathepsin B and Cathepsin K Inhibitor L-006235-1 Family 19 75
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Adenosine receptor A2b and Adenosine receptor A2a ligand SureC... 1 26
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-07ZDR2 f... 7 33
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
Neuropeptide Y receptor type 5 and Potassium voltage-gated cha... 2 0
Dipeptidyl peptidase 8 and Dipeptidyl peptidase 9 inhibitor AG... 3 3
Thyroid hormone receptor beta and Ferritin light chain ligand ... 3 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 13
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Serine/threonine-protein kinase Chk1 inhibitor 2-(1H-indol-5-y... 2 2
Serine/threonine-protein kinase Chk1 inhibitor 2-(1-benzothiop... 4 6
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-[4-(4-phenyl-1,3-t... 3 4
Cathepsin K and Cathepsin L1 inhibitor (2R)-N-(cyanomethyl)-4-... 2 1
Metabotropic glutamate receptor 5 ligand 5-methyl-N-(4-methyl-... 1 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 0
Serine/threonine-protein kinase Chk1 inhibitor 2-indazol-1-yl-... 4 5
MAP kinase-activated protein kinase 2 inhibitor 2-[(4,4-dimeth... 11 11
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 5 0
Probable G-protein coupled receptor 142 ligand (2S)-3-phenyl-N... 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00420534 CHEMBL2381114 Bioactive 2-(1,3-dihydroisoindol-2-yl)-N-(4-piperazin-1-ylpyridin-3-yl)-1,3-thiazole-4-carboxamide
CFAMM00420539 CHEMBL2381238 Bioactive 2-(1,3-dihydroisoindol-2-yl)-N-(2-piperazin-1-ylphenyl)-1,3-thiazole-4-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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