CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13130
Family Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform inhibitor 2-[4-[2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazol-8-yl]pyrazol-1-yl]ethanol family
No. of Seeds 13 No. of Other Members 1
Family Centroid CFAMM00420605 Functional Category Bioactive
Superfamily Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Binder Superfamily 2
Class Class 3551

Cousin Family NamesSeedsMembers
Rho-associated protein kinase 2 inhibitor SureCN13457044 family 1 17
Aurora kinase A inhibitor SureCN208325 family 1 5
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
LIM domain kinase 2 and LIM domain kinase 1 inhibitor N-[5-[6-... 1 22
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 6 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 14 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 12 2
Tyrosine-protein kinase ITK/TSK and Tyrosine-protein kinase Lc... 2 6
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-(3-c... 3 3
Corticotropin-releasing factor receptor 1 ligand 2-[1-[1-(4-me... 5 4


External ID

Functional Category

Molecule Name

CFAMM00420612 CHEMBL2381380 Bioactive 1-[4-[2-(5-amino-2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazol-8-yl]pyrazol-1-yl]-2-methylpropan-2-ol
CFAMM00420605 CHEMBL2381373 Bioactive 2-[4-[2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazol-8-yl]pyrazol-1-yl]ethanol
CFAMM00420613 CHEMBL2381375 Bioactive 8-[1-(methylsulfonylmethyl)pyrazol-4-yl]-2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazole
CFAMM00420611 CHEMBL2381382 Bioactive 2-[4-[2-(5-amino-2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazol-8-yl]pyrazol-1-yl]ethanol
CFAMM00420604 CHEMBL2381271 Bioactive 8-(1-methylimidazol-4-yl)-2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazole
CFAMM00420610 CHEMBL2381269 Bioactive 2-(2-propan-2-yl-1,2,4-triazol-3-yl)-8-(1H-pyrazol-4-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazole
CFAMM00420608 CHEMBL2381378 Bioactive 2-[4-[2-(5-methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazol-8-yl]pyrazol-1-yl]ethanol
CFAMM00420607 CHEMBL2381377 Bioactive 2-methyl-2-[4-[2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazol-8-yl]pyrazol-1-yl]propanamide
CFAMM00420606 CHEMBL2381376 Bioactive 2-[4-[2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazol-8-yl]pyrazol-1-yl]ethanamine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

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Professor in Department of Pharmacy
National University of Singapore, Singapore

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