CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13158
Family Name Hepatocyte growth factor receptor ligand 1-(2-chlorophenyl)-N-[3-fluoro-4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinolin-4-yl]oxyphenyl]-4-oxocinnoline-3-carboxamide family
No. of Seeds 14 No. of Other Members 8
Family Centroid CFAMM00420843 Functional Category Bioactive
Superfamily Huntingtin and Prelamin-A/C Binder Superfamily 37
Class Class 3457

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 67 130
Vascular endothelial growth factor receptor 2 Ligand E 7080 Fa... 7 17
Tivozanib family 4 6
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS5MA ... 3 4
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Platelet-derived growth factor receptor beta and Receptor-type... 6 5
Platelet-derived growth factor receptor beta and Receptor-type... 5 1
Platelet-derived growth factor receptor beta and Macrophage co... 1 4
Platelet-derived growth factor receptor alpha and Mast/stem ce... 2 2
Hepatocyte growth factor receptor and Vascular endothelial gro... 14 10
Protein-tyrosine kinase 2-beta and Focal adhesion kinase 1 inh... 3 6
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 11 7
Hepatocyte growth factor receptor ligand 1-[(E)-(2,4-difluorop... 2 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN4854955 f... 2 0
Vascular endothelial growth factor receptor 2 ligand 6-(6,7-di... 4 0
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Vascular endothelial growth factor receptor 2 and Tyrosine-pro... 4 0
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 9 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
Macrophage colony-stimulating factor 1 receptor ligand 4-(3-ch... 5 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00420842 CHEMBL2385193 Bioactive 1-(2,6-dichlorophenyl)-N-[3-fluoro-4-[6-methoxy-7-[3-(4-methylpiperidin-1-yl)propoxy]quinolin-4-yl]oxyphenyl]-4-oxocinnoline-3-carboxamide
CFAMM00420855 CHEMBL2385186 Bioactive 1-(2,6-dichlorophenyl)-N-[3-fluoro-4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinolin-4-yl]oxyphenyl]-4-oxocinnoline-3-carboxamide
CFAMM00420841 CHEMBL2385190 Bioactive N-[3-fluoro-4-[6-methoxy-7-[3-(4-methylpiperidin-1-yl)propoxy]quinolin-4-yl]oxyphenyl]-4-oxo-1-[3-(trifluoromethyl)phenyl]cinnoline-3-carboxamide
CFAMM00420840 CHEMBL2385197 Bioactive 1-(3,4-difluorophenyl)-N-[3-fluoro-4-[6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-yl]oxyphenyl]-4-oxocinnoline-3-carboxamide
CFAMM00420839 CHEMBL2385194 Bioactive 1-[4-chloro-3-(trifluoromethyl)phenyl]-N-[3-fluoro-4-[6-methoxy-7-[3-(4-methylpiperidin-1-yl)propoxy]quinolin-4-yl]oxyphenyl]-4-oxocinnoline-3-carboxamide
CFAMM00420852 CHEMBL2385175 Bioactive 1-(2-chlorophenyl)-N-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-4-oxocinnoline-3-carboxamide
CFAMM00420845 CHEMBL2385206 Bioactive 1-(4-bromophenyl)-N-[3-fluoro-4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinolin-4-yl]oxyphenyl]-4-oxocinnoline-3-carboxamide
CFAMM00420838 CHEMBL2385199 Bioactive 1-[2-chloro-5-(trifluoromethyl)phenyl]-N-[3-fluoro-4-[6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-yl]oxyphenyl]-4-oxocinnoline-3-carboxamide
CFAMM00420851 CHEMBL2385189 Bioactive 1-(2-bromophenyl)-N-[3-fluoro-4-[6-methoxy-7-[3-(4-methylpiperidin-1-yl)propoxy]quinolin-4-yl]oxyphenyl]-4-oxocinnoline-3-carboxamide
CFAMM00420844 CHEMBL2385205 Bioactive 1-(4-chlorophenyl)-N-[3-fluoro-4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinolin-4-yl]oxyphenyl]-4-oxocinnoline-3-carboxamide
CFAMM00420837 CHEMBL2385198 Bioactive 1-(2,6-dichlorophenyl)-N-[3-fluoro-4-[6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-yl]oxyphenyl]-4-oxocinnoline-3-carboxamide
CFAMM00420850 CHEMBL2385185 Bioactive 1-(2,4-dichlorophenyl)-N-[3-fluoro-4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinolin-4-yl]oxyphenyl]-4-oxocinnoline-3-carboxamide
CFAMM00420843 CHEMBL2385201 Bioactive 1-(2-chlorophenyl)-N-[3-fluoro-4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinolin-4-yl]oxyphenyl]-4-oxocinnoline-3-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

44300 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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