CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13162
Family Name 72 kDa type IV collagenase and Matrix metalloproteinase-9 inhibitor (2R)-2-[[4-[(4-fluorobenzoyl)amino]phenyl]sulfonylamino]-3-(1H-indol-3-yl)propanoic acid family
No. of Seeds 4 No. of Other Members 1
Family Centroid CFAMM00420869 Functional Category Bioactive
Superfamily Fatty acid-binding protein, adipocyte Inhibitor 2-(3-methyl-indole-1-sulfonyl)-benzoic Acid Superfamily
Class Class 2185

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
HIV protease Inhibitor Saquinavir Family 64 428
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
Fibroblast growth factor receptor 1 and Aurora kinase B Inhibi... 4 51
Substance-P receptor Ligand GSK424887 Family 8 184
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Thromboxane-A synthase Inhibitor CGS-22652 Family 37 95
Fatty acid-binding protein, adipocyte Inhibitor 2-(3-methyl-in... 5 9
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Angiotensin-converting enzyme and Endothelin-converting enzyme... 2 10
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
Endothelin B receptor Ligand IRL-2500 Family 34 87
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Thromboxane A2 receptor and Thromboxane-A synthase ligand AGN-... 4 19
Cholecystokinin receptor type A ligand A-65186 family 2 6
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Cathepsin L1 inhibitor Bio2_000267 family 9 1
Aurora kinase A and Aurora kinase B inhibitor SureCN3802769 fa... 2 20
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 3
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 4
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 5 1
Prostaglandin D2 receptor 2 ligand 2-[1-(4-benzamidobenzoyl)is... 4 9
Pol polyprotein inhibitor AC1LAHQ9 family 8 15
Pancreatic alpha-amylase and Gastrin/cholecystokinin type B re... 7 1
C-C chemokine receptor type 2 ligand 2-[4-(5-amino-1H-indol-3-... 3 2
Tankyrase-1 inhibitor N-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1... 3 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 3
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 1 1
Hepatocyte growth factor receptor and Protein-tyrosine kinase ... 2 15
Gastrin/cholecystokinin type B receptor ligand (2R)-2-[[5-(8-a... 2 3
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Tyrosine-protein kinase Yes and Proto-oncogene tyrosine-protei... 7 18
Neprilysin and Endothelin-converting enzyme 1 inhibitor (2S)-2... 5 0
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 3 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1
Angiotensin-converting enzyme and Endothelin-converting enzyme... 1 0
Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor [2-(me... 1 0
Calcium/calmodulin-dependent protein kinase type II subunit de... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00420869 CHEMBL2385441 Bioactive (2R)-2-[[4-[(4-fluorobenzoyl)amino]phenyl]sulfonylamino]-3-(1H-indol-3-yl)propanoic acid
CFAMM00420868 CHEMBL2385442 Bioactive (2R)-3-(1H-indol-3-yl)-2-[[4-[(4-iodobenzoyl)amino]phenyl]sulfonylamino]propanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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