CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13198
Family Name Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0YSZ family
No. of Seeds 10 No. of Other Members 0
Family Centroid CFAMM00421035 Functional Category Bioactive
Superfamily Metabotropic glutamate receptor 5 Ligand 3-chloro-n-(6-chloropyridin-2-yl)benzamide Superfamily
Class Class 2337

Cousin Family NamesSeedsMembers
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Transient receptor potential cation channel subfamily V member... 16 295
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
XL-888 family 16 85
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
Tubulin beta chain Inhibitor 2-(3-chloro-phenyl)-1h-[1,8]napht... 3 13
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Metabotropic glutamate receptor 5 Ligand 3-chloro-n-(6-chlorop... 2 5
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Peroxisome proliferator-activated receptor gamma Ligand 2-chlo... 5 19
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 6-(4-... 3 6
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Adenosine receptor A3 ligand AGN-PC-07N4XX family 6 10
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
RAC-alpha serine/threonine-protein kinase inhibitor SureCN4728... 11 6
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Nicotinamide phosphoribosyltransferase inhibitor 4-[(7-chloro-... 6 4
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 9
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 2
Coagulation factor X inhibitor AGN-PC-078Y4E family 4 6
Hepatocyte growth factor receptor and Insulin receptor ligand ... 4 15
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Coagulation factor X and Kallikrein-1 inhibitor SureCN890858 f... 5 6
Coagulation factor X inhibitor AGN-PC-078Y3A family 4 1
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 1 0
Nicotinamide phosphoribosyltransferase inhibitor 4-[[(7-chloro... 1 1
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
G1/S-specific cyclin-E2 and G1/S-specific cyclin-E1 inhibitor ... 5 10
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 3 6
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X3N ... 1 7
Cell division cycle 7-related protein kinase and Dual specific... 3 1
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 3 0
Aurora kinase A inhibitor Bisanilinopyrimidine, 6j family 2 1
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 0
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
Metabotropic glutamate receptor 5 ligand 5-(4-chlorophenyl)-1,... 3 1
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0Z0U... 2 0
Non-receptor tyrosine-protein kinase TYK2 ligand SureCN1298914... 3 0
Non-receptor tyrosine-protein kinase TYK2 ligand SureCN3514789... 1 0
Coagulation factor X inhibitor 5-bromo-N-(5-chloropyridin-2-yl... 1 1
Coagulation factor X inhibitor AGN-PC-078Y0S family 7 1
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Thromboxane-A synthase inhibitor 6-chloro-3-(4-imidazol-1-ylbu... 12 21
Coagulation factor X inhibitor AGN-PC-078Y0T family 11 0
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Coagulation factor X inhibitor N-[2-[(5-chloropyridin-2-yl)sul... 1 0
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Macrophage colony-stimulating factor 1 receptor ligand N-[3-[(... 5 0
P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin... 3 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 1 0
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-[(2,6... 1 1
Cannabinoid receptor 2 ligand SureCN13503317 family 7 7
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 1 0
Potassium voltage-gated channel subfamily KQT member 3 and Pot... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00421040 CHEMBL2387134 Bioactive SureCN13032747
CFAMM00421039 CHEMBL2387122 Bioactive AGN-PC-0D0YV8
CFAMM00421038 CHEMBL2387124 Bioactive AGN-PC-0D0YWR
CFAMM00421037 CHEMBL2387125 Bioactive AGN-PC-088H38
CFAMM00421043 CHEMBL2387225 Bioactive AGN-PC-0D0YYB
CFAMM00421036 CHEMBL2387119 Bioactive SureCN3717186
CFAMM00421042 CHEMBL2387223 Bioactive SureCN3514969
CFAMM00421035 CHEMBL2387118 Bioactive AGN-PC-0D0YSZ
CFAMM00421041 CHEMBL2387221 Bioactive SureCN3514264
CFAMM00421034 CHEMBL2387110 Bioactive AGN-PC-0D0YXQ

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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