CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM13217
Family Name Prostaglandin E synthase inhibitor 2-(2-chloro-6-fluorophenyl)-7-phenyl-3,5-dihydroimidazo[4,5-c]quinolin-4-one family
No. of Seeds 9 No. of Other Members 1
Family Centroid CFAMM00421099 Functional Category Bioactive
Superfamily Prostaglandin E synthase and Cytochrome P450 2C9 Binder Superfamily
Class Class 3039

Cousin Family NamesSeedsMembers
Poly [ADP-ribose] polymerase 1 inhibitor 2-(3-chlorophenyl)-1H... 4 38
Adenosine receptor A1 ligand SureCN10614388 family 5 1
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 9
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 8 13
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 8
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 12
Serine/threonine-protein kinase Chk2 inhibitor SureCN3922132 f... 3 2
Coagulation factor X inhibitor SureCN8289965 family 4 5
Prostaglandin E synthase and Cytochrome P450 2C9 inhibitor 7-b... 1 7
Casein kinase II subunit alpha and Serine/threonine-protein ki... 1 5
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 2
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 7 15
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 2 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Prostaglandin E synthase inhibitor AGN-PC-04SSMB family 6 0
Prostaglandin E synthase inhibitor AGN-PC-07CRKH family 1 0
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Sonic hedgehog protein and Cytochrome P450 2C9 inhibitor AGN-P... 1 0


External ID

Functional Category

Molecule Name

CFAMM00421097 CHEMBL2387507 Bioactive 2-(2-chloro-6-fluorophenyl)-7-(2-chlorophenyl)-3,5-dihydroimidazo[4,5-c]quinolin-4-one
CFAMM00421096 CHEMBL2387504 Bioactive 2-(2-chloro-6-fluorophenyl)-7-(2-methylphenyl)-3,5-dihydroimidazo[4,5-c]quinolin-4-one
CFAMM00421095 CHEMBL2387505 Bioactive 2-(2-chloro-6-fluorophenyl)-7-(3-methylphenyl)-3,5-dihydroimidazo[4,5-c]quinolin-4-one
CFAMM00421101 CHEMBL2387588 Bioactive 2-(2-chloro-6-fluorophenyl)-7-(4-chlorophenyl)-3,5-dihydroimidazo[4,5-c]quinolin-4-one
CFAMM00421094 CHEMBL2387599 Bioactive 2-(2-chlorophenyl)-7-phenyl-3,5-dihydroimidazo[4,5-c]quinolin-4-one
CFAMM00421102 CHEMBL2387587 Bioactive 2-(2-chloro-6-fluorophenyl)-7-(3-chlorophenyl)-3,5-dihydroimidazo[4,5-c]quinolin-4-one
CFAMM00421100 CHEMBL2387502 Bioactive 2-(2-chloro-6-nitrophenyl)-7-phenyl-3,5-dihydroimidazo[4,5-c]quinolin-4-one
CFAMM00421099 CHEMBL2387503 Bioactive 2-(2-chloro-6-fluorophenyl)-7-phenyl-3,5-dihydroimidazo[4,5-c]quinolin-4-one
CFAMM00421098 CHEMBL2387506 Bioactive 2-(2-chloro-6-fluorophenyl)-7-(4-methylphenyl)-3,5-dihydroimidazo[4,5-c]quinolin-4-one

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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